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Faculty in Chemical Sciences Department




Dr. N. Shankaraiah

Associate Professor - Department of Chemical Sciences
E-Mail: shankar.niperhyd@gov.in

His area of research interest is Design and synthesis of new chemical entities of anticancer agents in ‘Drug Discovery’; Asymmetric synthesis; Combinatorial chemistry (Solid-/solution-phase); Development of alternative sustainable technologies in pharmaceutical sciences – Green chemistry; Exploration of new synthetic methodologies including ‘Online Mechanistic Investigations by ESI-MS/MS”.

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Dr. Srinivas Nanduri

Professor
E-Mail: nanduri.niperhyd@gov.in

Accomplished Medicinal, Synthetic and Natural Product Organic Chemist with 30 years of industrial and academic research experience. Associated with the Indian Pharma, CRO and reputed academic institutions viz., Dr Reddy's Laboratories, Aurigene Discovery Technologies Ltd., Biocon BMS Research Centre, Albany Molecular Research, Sri Sathya Sai Institute of Higher Learning and National Institute of Pharmaceutical Education & Research, Hyderabad in various positions and roles of scientific and managerial responsibilities. Led several integrated drug discovery programs encompassing all stages of drug discovery viz., Hit generation, Hit to Lead and Lead optimization involving both Natural Product and Synthetic products in the areas of oncology, metabolic disorders, and infectious diseases. The programs carried out include both internal programs and collaborative research programs with several pharmaceutical companies/Institutes. While some of the programs have successfully transitioned to the late Lead Optimization stages (pre-clinical/clinical), one of the programs has led to a Phase 2 clinical candidate. Experienced in leading cross-functional teams which include Medicinal Chemistry, biochemistry, pharmacology, DMPK and toxicology. Several patents/publications have been filed/published.

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Dr. Y.V. Madhavi

Assistant Professor
E-Mail: yvmadhavi.niperhyd@gov.in

Her area of research interest is synthesis of biologically active molecules. She has worked on the total synthesis of Cyclamenol-A an anti-inflammatory agent isolated from streptomyces species. It is a polyene macrolactum with seven double bonds of which only one is cis and the rest are trans double bonds. She has also worked on the development of some novel methodologies using Yb(OTf)3 , montmorillonite clay etc.

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Dr. Priyanka Bajaj

Assistant Professor
E-Mail: pbajaj.04@niperhyd.ac.in

Dr. Priyanka Bajaj’s group has particular interest in green chemistry to make our pharmaceutical and fine chemical industry and industrial products more environmentally friendly and affordable for everyone. Her research mainly focuses on developing green biocatalytic processes and enzymes for complex synthetic chemistry challenges mainly focusing on synthesis of chiral compounds of pharmaceutical importance. The enzymes are studied in detail for their structure activity relationship and engineered using the techniques of directed evolution. The libraries of various substrates and enzymes are further screened in high throughput mode using LC/MS, GC/MS and UV-Vis spectrophotometry and upscale and downscale processes are optimized. The group is working on exploring wide range of enzymes including Aldehyde dehydrogenases (ALDHs), Myoglobin, P450s and others.


Her Research Interest includes the below


  • Biocatalysis and Biotransformations
  • Green Chemistry
  • Protein based Biotherapeutics (Biosimilars/Biobetters)
  • Bioeconomic process development for pharmaceutical Industry
  • Enzymology
  • Recombinant protein engineering and evolution in E.coli and yeast based expression systems

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Dr. K. Venkata Rao

Assistant Professor
E-Mail: kvenkata.rao@niperhyd.ac.in

Dr Venkata Rao Kaki lab is working on discovery of novel Anti-diabetic agents, Anti-inflammatory agents and Anti-proliferative agents. The research works include identification of NCEs and development of new synthetic methodologies for NCEs. The lab works are focused on Benzazepinone based, Indole based derivatives and Natural products for DYRK1A, GSK-3β and pancreatic β-cells regenerating activity.

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