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Accomplished Medicinal, Synthetic and Natural Product Organic Chemist with 30 years of industrial and academic research experience. Associated with the Indian Pharma, CRO and reputed academic institutions viz., Dr Reddy's Laboratories, Aurigene Discovery Technologies Ltd., Biocon BMS Research Centre, Albany Molecular Research, Sri Sathya Sai Institute of Higher Learning and National Institute of Pharmaceutical Education & Research, Hyderabad in various positions and roles of scientific and managerial responsibilities. Led several integrated drug discovery programs encompassing all stages of drug discovery viz., Hit generation, Hit to Lead and Lead optimization involving both Natural Product and Synthetic products in the areas of oncology, metabolic disorders, and infectious diseases. The programs carried out include both internal programs and collaborative research programs with several pharmaceutical companies/Institutes. While some of the programs have successfully transitioned to the late Lead Optimization stages (pre-clinical/clinical), one of the programs has led to a Phase 2 clinical candidate. Experienced in leading cross-functional teams which include Medicinal Chemistry, biochemistry, pharmacology, DMPK and toxicology. Several patents/publications have been filed/published.
Full Profile
Dr. Janani Radhakrishnan’s research focus on biofabrication of tissue-mimetic preformed and injectable polymeric scaffolds for regenerative medicine and 3D organotypic models. Her interest includes tissue engineered scaffolds particularly, injectable hydrogels, spatially varying gradient hydrogels, pneumatic based 3D bioprinted constructs, random / aligned / core-shell electrospun nanofibers, protein nanoparticles, SPIONs, nanomicellar and nanotheranostic systems. The developed biomaterials are characterized, investigated in vitro using cells / stem cells and in vivo regenerative potential assessed in rat / rabbit models. In addition, the potential of mesenchymal stem cells will be explored by integrating with developed artificial matrices.
