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Faculty Profile : Dr. Amit Asthana

Name: Dr. Amit Asthana


Associate Professor & Head, Department of Medical Devices
amit.asthana@niperhyd.ac.in, amitasthana4@gmail.com
+91 9666244410
+91-040-23074750 (Ext. No: 2012)
Google Scholar Citations


ADDRESS, ROOM NO

Department of Pharmaceutical Analysis
Room no: 47
NIPER Hyderabad
Balanagar, Hyderabad-500037, TS, INDIA



QUALIFICATION: (REVERSE CHRONOLOGICAL ORDER)

  • Ph.D (Chemistry) - 1995-2000 - Barkatullah University, Bhopal, India
  • M. Sc. (Appl. Chem.) - 1993 - 1995 - Barkatullah University, Bhopal, India
  • B. Sc. (Chem. And Biol.) - 1990 - 1993 - Barkatullah University, Bhopal, India

Please Click here for more information regarding Advanced training Received.

EXPERIENCE

  • Associate Professor, 2021 - Till date at NIPER, Hyderabad, India
  • Senior Principal Scientist, 2019 – 2021 at CSIR-CCMB, Hyderabad, India
  • Principal Scientist, 2013 – 2019 at CSIR-CCMB, Hyderabad, India
  • Ramalingaswami Fellow, 2011 – 2013 at CSIR-CCMB, Hyderabad, India
  • Senior Professional Officer, 2008 – 2011 at ANFF(QLD-Node), UQ, Brisbane, Australia
  • Brainpool Invited Professor, 2006 – 2008 at Chugnam National University, South Korea
  • Assistant Professor & HOD, 2005 – 2006 at ACEAR, Ambala, India
  • Assistant Professor, 2005 at Rai Foundation College, Faridabad, India
  • Research Professor, 2004 – 2005 at Chugnam National University, South Korea
  • Quick Hire Scientist, 2003 – 2004 at CSIR-AMPRI, Bhopal, India
  • Post-doctoral RA, 2001 – 2003 at UIUC, Urbana-Champaign, USA
  • Curie Post-doctoral Fellow, 2000 – 2001 at Institute Curie, France
  • Visiting Research Fellow, 1997 – 1998 at University of Amsterdam, The Netherlands
  • Doctoral Scholar, 1995 – 2000 at CSIR-AMPRI, Bhopal, India



COURSES HANDLING(PHD/M.PHARM)

M.Tech. Medical Devices:

  • MD-112: Medical Instrumentation (Diagnostic, Therapeutic & Surgical)
  • MD-116: Biomedical devices and systems (Elective 1)
  • MD-214: Biosensor

M.Pharma. Pharmaceutical Analysis:

  • NP-640: Bioanalysis
  • Ph.D. Pharmaceutical Analysis:

    • PA-740: Liquid Chromatography in Pharmaceutical Analysis



    PHD STUDENTS/MASTERS STUDENTS

    PostDoc: 04 (Completed)
    Ph.D: 01 (ongoing)
    M. Tech: 23 (Awarded)
    UG Thesis:24 (Awarded)

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    AWARDS / HONOURS
    • Fellow of Telangana Academy of Science, Hyderabad, July 2017
    • Award of Honor, as Distinguished Speaker at Lab-on-a-Chip and Microfluidic Conference, SelectBio India, 2019.
    • Award of Honor, as Distinguished Speaker at Lab-on-a-Chip and Microfluidic Conference, SelectBio, 2013.
    • 2nd best poster award, Polymer-Derived Ceramics and Their Applications Symposium, 11th ACC 2005, Seoul, Korea, 2005.
    • Award of Merit, Modern Trends in Engineering and Technology, SATI, Vidisha, India, 1995.


    RESEARCH AREAS/INTEREST

      Early diagnosis of infections, genetic disorders, and metabolic disorders are some of the most serious challenges to the health care system worldwide, especially in India, and are essential in the management of infection/disease, treatment decisions, and response to treatment. The current diagnostic tools include (1) serological assays, (2) molecular assays, and (3) routine biochemical tests. All these methods lack accuracy, require trained technicians, are expensive as well as time-consuming. In my group, we are involved in developing diagnostic tools that are “affordable”; for example, developing microfluidic paper-based analytical devices (µPAD) or paper-microfluidic devices coupled with an instrument-free or portable device, which is coupled with ambient temperature amplification technology while using optical and/or electrochemical detection system for quantification of nucleic acid (NA). Apart from this, my group is also interested in developing:

    • Paper-based devices as Raman immune--sensor.
    • Non-conventional methods to fabricate microfluidic devices.
    • Biopolymer microfluidic devices for tissue engineering and cell culture.
    • 3D printing and 3D cell culture.
    • Generation of "site targeted" drug delivery vectors for drug delivery and diagnosis, using microfluidic devices.


    FELLOWSHIPS / GRANTS
    • Ramalingaswami Fellowship, DBT, India, 2011-2016
    • Brainpool Fellowship, KOFST, S. Korea, 2007-2009
    • Research Professorship, Chungnam National University, South Korea, 2004-2005
    • Quick Hire Fellowship (Range-2) CSIR, India, 2003-2004.
    • DARPA Post-Doctoral Fellowship, UICU, IL, USA, 2001-2003.
    • Curie Post-Doctoral Fellowship, Paris, France, 2000-2001.
    • Senior Research Fellowship, CSIR, India, 1999-2000.
    • Visiting Research fellowship, Indo-EU joint research project, Amsterdam, The Netherlands, 1997-1998
    • Research fellowship, Indo-EU joint research project, CSIR- AMPRI, Bhopal, India

    PUBLICATIONS / BOOK CHAPTERS

    Few Selective Publications:

    1. Long-term stabilization of blood typing antibodies using a bioactive paper-based microfluidic device, Shahila Parween, Ira Bhatnagar, Suchitra Bhosale, Shivangi Paradkar, Issac. J. Michael, Ch. Mohan Rao, Amit Asthana*, Int. J. Biol. Macromol., 15 November 2020,163, 1233-1239. (Impact factor 5.162)
    2. An affordable, rapid determination of total lipid profile using a paper-based microfluidic device, ShahilaParween, P. Debishree Subudhi, Amit Asthana, Sensors & Actuators: B. Chemical, 2019, 285, 405–412. (Impact factor 7.1)
    3. Fabrication of cost-effective and efficient paper-based device for viscosity measurement, Anirudh Rayaprolu; Saurabh K Srivastava; LavleenBhati; Ketan Anand; Amit Asthana, Ph.D.; Ch. Mohan Rao, Analytica Chimica Acta, 2018, 1044,86-92. (Impact factor 5.977)
    4. Chitosan as a biomaterial in drug delivery and tissue engineering, S. M. Ahsan. M. Thomas, K. K. Reddy, S. G. Sooraparaju, A. Asthana, I. Bhatnagar, Int. J. Biol. Macromol., 2018, 110, 97-109. (Impact factor 5.162)
    5. Chitosan stabilized gold nanoparticle-mediated self-assembled gliPnanobiosensor for diagnosis of Invasive Aspergillosis, I. Bhatnagar, K. Mahato, K. K. R. Ealla, A. Asthana, P. Chandra, Int. J. Biol. Macromol., 2018, 110, 449-456. (Impact factor 5.162)
    6. Foil assisted replica molding for the fabrication of microfluidic devices and their application in vitro, Issac J. Micheal, Aditya J. Vidyasagar, Kiran Kumar Bokara, Naveen Kumar Mekala, Amit Asthana and Ch Mohan Rao, Lab-on-a-chip,2014, 14 (19), 3695 –3699. (Impact factor 6.750)
    7. Fabrication and Characterization of Gold Nanohole Electrode Ensemble, S. Rauf, M.J.A. Shiddiky, A. Asthana, K. Dimitrov, Sensors & Actuators: B Chemical, 2012, 173, 491-496. (Impact factor 7.10)
    8. A facile single-step fabrication of microchannels with varying sizes A. Asthana, K. O. Kim, J. Perumal, D. M. Kim, D. P. Kim, Lab-on-a-chip, 2009, 9, 1138 – 1142. (Impact factor 6.750)
    9. Novel transparent polysilazane derived solvent resistant, biocompatible microchannels and substrates: application in microsystem technology, A. Asthana, Y. Asthana, I. K. Sung, D. P. Kim, Lab-on-a-Chip, 2006, 6, 1200-1204. (Impact factor 6.750)
    10. DNA mutation analysis based on capillary electrochromatography using colloidal poly (n-isopropyl acrylamide) particles as pseudo stationary phase, J. M. Song, A. Asthana, D. P. Kim, Talanta, 2006, 68, 940-944. (Impact factor 5.339)
    11. Rapid determination of sulfonamides in meat and milk by micellar electrokinetic chromatography with fluorescence detection, S. Mehra, S. K. Sanghi, A. Asthana, M. Shelke, M. Sharma, Analytica Chimica Acta, 2005, 552, 100-115. (Impact factor 5.31)
    12. Fast separation and sensitive detection of carcinogenic aromatic amines by reversed-phase liquid chromatography coupled with the electrochemical detector, M. Shelke, S. K. Sanghi, A. Asthana, S. Mehra, M. Sharma, Journal of Chromatography A, 2005, 1089, 52–58. (Impact factor 4.049)
    13. Fabrication and characterization of a silicon-based millimetre scale, microfabricated PEM fuel cell operating with gaseous hydrogen, methanol, and formic acid as fuels, J. Yeom, G.Z.Mozsgai, B.R.Flachsbart, E.R. Choban, A. Asthana, P.J.A. Kenis, M.A. Shannon, Sensors and Actuators-B: Chemical, 2005, B 107, 882-891. (Impact factor 7.10)
    14. Determination of aromatic amines in a water sample by capillary electrophoresis with electrochemical and fluorescence detection, A. Asthana, D. Bose, A. Durgbanshi, S. K. Sanghi, W. Th. Kok, J. Chromatography A, 2000, 895, 197-203. (Impact factor 4.049)

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    PATENTS
    1. A novel facile aqueous-based extraction of progesterone metabolites from faeces sample for non-invasive, simple, affordable and farmer-friendly paper-based kit for pregnancy detection in cattle and buffaloes, G. Umapathy, Amit Asthana, Chintalagiri Mohan Rao, Vinod Kumar, Gopi Suresh Oggu; Indian Patent, Application number 201911008655, Filed on March 06, 2019 Publication number 201911008655 dated September 18,2020.
    2. A novel facile aqueous-based extraction of progesterone metabolites from faeces sample for non-invasive, simple, affordable and farmer-friendly paper-based kit for pregnancy detection in cattle and buffaloes, G. Umapathy, Amit Asthana, Chintalagiri Mohan Rao, Vinod Kumar, Gopi Suresh Oggu; PCT International Application No. PCT/IN2020/050202 Filed on March 05, 2020, Claiming Priority from Indian Application No.: 201911008655, Publication number WO/2020/178857, dated September 10, 2020.
    3. A rapid, low-cost process for the preparation of SERS substrate and SERS substrate prepared thereby, Amit Asthana, Mohan Rao Chintalagiri, Saurabh Kumar Srivastava, Gopi Suresh Oggu; Indian Patent, Application number 201811023895, Filed on June 27, 2018, Publication number 201811023895 dated January 03, 2020.
    4. A rapid, low-cost process for the preparation of SERS substrate and SERS substrate prepared thereby, Amit Asthana, Mohan Rao Chintalagiri, Saurabh Kumar Srivastava, Gopi Suresh Oggu; PCT International Application No. PCT/IN2019/050102, Filed on February 08, 2019, Claiming Priority from Indian Application No.: 201811023895, Publication number WO/2020/003321 dated January 02, 2020.
    5. Method of producing size-controlled uni- and multilamellar echogenic lipospheres; Australian provisional patent, application no.AU2010902691, 2010.


    INVITED TALKS

    50

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    SPONSORED PROJECTS

    1. Affordable Paper-based microfluidic devices for HCV diagnosis, Mission Mode project on “Nano-Biosensors and Microfluidics for Health Care” Grant No.: HCP0012, Funding ₹ 3,74,70,000/- (US$ ~528,250.00), Duration 2 years, 2018-2020.
    2. Paper-based affordable microfluidic kit for early pregnancy detection in cattle and buffaloes; CSIR-Fast Track Translational Research Grant, Project Number BS/FTT/2016-PPD, Funding ₹ 63,52,000/- (US$ ~89,550.00), Duration 2 years, August 2016 to August 2018.
    3. Development of paper-based biochemical sensors/assay and novel approach to synthesize nanoparticles for detection enhancement, CSIR Network project titled Nano-materials: Applications and Impact on Safety, Health and Environment (NanoSHE) Grant No.: BSC0112, Funding ₹ 30,00,000/- (U S$ ~42,300.00), Duration 5 years, 2012-2017.
    4. High throughput proteomic analysis using the microfluidic platform to understand wound healing mechanism; Grant under Ramalingaswami Fellowship, Department of Biotechnology, Government of India, Project Number P90807, Funding Rs.74,50,000/-(~US$ 143,500, Duration 5 years, August 2011 to August 2016.
    5. Fabrication of multilayer mold using maskless direct writing on dry film photo-resist for rapid prototyping of multidimensional microfluidic device; New Staff Research Start-up project, University of Queensland, Grant Number 2009001393, Funding AU$ 12,000, Duration 01 Year 3 months August 2009-December 2010.
    6. Single nucleotide polymorphism detection using a MEMS device with microchannels filled with separation particles; Korea Research Foundation, South Korea, Grant No. KRF-2004-042-103115, Funding US$ 60,000, Duration 01 Year January 2005-December 2005.
    7. Design, fabrication and testing of fuel storage and delivery chamber for Si-based micro-fuel cells and Design, fabrication and testing of Si-based bioreactor for fuel cells, A part of the project on Fuel Cells funded by CSIR Governing body under NMITLI project, Total cost of both the project US$ 260,000, Duration: 4 years starting from June 2004.
    Laboratory facilities developed for research / teaching.

    1. Established facilities for fabricating a paper-based microfluidic device, CCMB.
    2. Established microfabrication facility for fabrication of PDMS-based microfluidic devices, CRTDH, CCMB.


    ADDITIONAL RESPONSIBILITIES

    Chairperson, Physical Verification of fix assets, NIPER, 2021

    Vice President of CSIR-CCMB Staff Club Since 2019-2021.

    Member for three internal and two statutory committees in CCMB

    1. Energy Conservation Cell Committee
    2. Transport Shuttle Service [CRF & LaCONES]
    3. Technology Assessment Group to help Innovation Cell-Committee [iHUB]
    4. CRTDH-Monitoring Committee [CTRDH]
    5. Standing Disposal Committee [Stores & Purchase]



    ANY OTHER INFORMATION

    Press Coverage to work

    1. Publication on the paper-based device to determine lipid profile is covered by The Hindu, published on Feb 02, 2019, with a title “CCMB uses a paper-based device to determine lipid profile”.
    2. Publication on the paper-based device to determine the lipid profile is covered by https://journosdiary.com/2019/02/02/ccmb-lipid-profile-microfluidic-device.
    3. Publication on paper-based viscosity is covered by Deccan Chronicle, Published on May 25, 2018, with the title “Paper filter to determine the viscosity of solutions” and by Andra Jyoti on 28th of May 2018.
    4. Publication on paper-based viscosity is covered by local language daily Andra Jyoti on 28th of May 2018
    5. Publication on GliPnanobiosensor for diagnosis of Invasive Aspergillosis, in Int. J. Biol. Macromol. was covered by Nature India Research Highlights, https://www.natureasia.com/en/nindia/article/10.1038/nindia.2018.25.
    6. New article on Non-invasive early test for pregnancy in cattle published in The Hindu, April 28, 2017, with the title “Non-invasive early test for pregnancy in cattle”.
    7. Publication on the selectively permeable calcium-alginate microfluidic device using modified embedded template method in Biomicrofluidics was selected as the featured article in the focused area of frontier research in the field of Biomicrofluidics and published on March 15, 2012 issue of Virtual Journal of Biological Physics Research, published by the American Physical Society and the American Institute of Physics.
    8. Publication on enzyme loaded alginate hollow microfiber in Biomicrofluidis was selected as the featured article in the focused area of frontier research in the field of Instrumentation and published on July 1, 2011 issue of Virtual Journal of Biological Physics Research, published by the American Physical Society and the American Institute of Physics.
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