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Faculty Profile : Dr. Vasundhra Bhandari

Name: Dr. Vasundhra Bhandari


Assistant Professor
vasundhra.b@niperhyd.ac.in, vasundhra23@gmail.com
+91 40 23074750 Extn- 2047
Google Scholar Citations


ADDRESS, ROOM NO


Department of Pharmacoinformatics
Room No: 28
NIPER Hyderabad
Department of Pharmaceuticals (Govt. of India)
Balanagar, Hyderabad - 500037, TS, INDIA



Experience

  1. Assistant Professor, Department of Pharmacoinformatics at NIPER Hyderabad - 2021 - Present
  2. DST Inspire Faculty at National Institute of Animal Biotechnology-DBT, Hyderabad - 2016 to 2020
  3. DST Inspire Faculty at University of Hyderabad, Hyderabad - Feb 2016 to Dec 2019
  4. Fast Track Young Scientist at National Institute of Animal Biotechnology-DBT, Hyderabad - 2015
  5. Research Associate at National Institute of Animal Biotechnology-DBT, Hyderabad - 2014



QUALIFICATION: (REVERSE CHRONOLOGICAL ORDER)

  1. PhD: Birla Institute of Science and Technology, Pilani - 2013
  2. M.Sc (Biochemistry): Jiwaji University, Gwalior - 2007
  3. B.Sc (Life Sciences): University of Delhi, Delhi - 2005



COURSES HANDLING(PHD/M.S(PHARM))

  1. M. Pharm: PC-640, PC-650 and MC-610 (Course coordinator).
  2. PhD: Nil

PHD STUDENTS/MASTERS STUDENTS

One PhD Student


AWARDS / HONOURS

  1. TWAS selected participant for International Conference for Young Scientist on Infectious Diseases, 2017.
  2. DST INSPIRE Faculty Award-2015
  3. Fast Track Young Scientist – (DST-SERB) 2014.
  4. Won the Sri Ramachari Young Scientist Award -May 15th 2012.
  5. Won International Travel Grant Award from European commission, 2010.
  6. Was awarded Scholar in 12th standard in 2002 for good conduct and performance during my 12 years in Lady Irwin School, New Delhi.


RESEARCH AREAS/INTEREST

Pharmacogenomics and Precision Medicine
Antimicrobial Resistance
Drug discovery



SPONSORED PROJECTS

  1. Science and engineering Research Board funded Fast track Young Scientist grant (NO. SB/YS/LS-65/2014) April, 2015 for three years.
  2. INSPIRE Faculty Award (DST/INSPIRE/04/2015/000242) Feb 2016 for five years.
  3. DST SERB grant Sep 2018 for project entitled “To investigate the mechanisms regulating the enigmatic Oxacillin susceptible mecA positive phenotype in the clinical isolates of Staphylococcus aureus.
  4. DRDO grant approved for project entitled Deciphering the Role of Efflux Pumps in Imparting Antimicrobial Resistance in MDR pathogens and their Inhibitors in Potentiating the Existing Therapy.
  5. Industry Sponsored project entitled: Development of Precision Diabetes tools using Omics approach for 1.07 crore for the period of two years starting from 2021.



FELLOWSHIPS / GRANTS

DST INSPIRE Faculty Fellowship Awardee 2015-2020.



PUBLICATIONS / BOOK CHAPTERS

  1. Brahma, Umarani; Sharma, Paresh; Murthy, Shweta; Sharma, Savitri; Chakraborty, Shalini; Appalaraju, Sundarapu Naga; Bhandari, Vasundhra. Decreased expression of femXAB genes and fnbp mediated biofilm pathways in OS-MRSA clinical isolates. Scientific report, 2019:9(1). Impact Factor: 4.259
  2. Umarani Brahma, Richa Kothari, Paresh Sharma, Vasundhra Bhandari. Antimicrobial and anti-biofilm activity of hexadentated macrocyclic complexes of copper (II) derived from thiosemicarbazide against Staphylococcus aureus. Scientific Reports, 8(1):8050, 2018. Impact Factor: 4.259.
  3. Mahato S, Mistry HU, Chakraborty S, Sharma P, Saravanan R, Bhandari V. Identification of Variable Traits among the Methicillin Resistant and Sensitive Coagulase Negative Staphylococci in Milk Samples from Mastitic Cows in India. Front Microbiol. 2017; 8:1446, Impact Factor: 4.07.
  4. Mistry H, Sharma P, Mahato S, Saravanan R, Kumar PA, Bhandari V. Prevalence and Characterization of Oxacillin Susceptible mecA-Positive Clinical Isolates of Staphylococcus aureus Causing Bovine Mastitis in India. PLoS One. 2016; 11(9): e0162256, Impact Factor: 3.53.
  5. Matlani M, Shende T, Bhandari V*, Dawar R, Sardana R, Gaind R*. Linezolid resistant mucoid Staphylococcus haemolyticus from a tertiary-care centre in Delhi. New Microbes New Infect. 2016; 11:57-8. (*Co-Corresponding author).
  6. Paresh Sharma, D Peddi Reddy, Neena George, Ramya Gadicherla, P.Anand Kumar, Vasundhra Bhandari. Draft genome of Staphylococcus aureus strain isolated from a clinical mastitis infected cattle. Genome Announc. 2015; 3(4). pii: e00914-15.
  7. George N, Bhandari V*, Sharma P. Phylogenetic relationship and genotypic variability in Anaplasma marginale strains causing anaplasmosis in India. Infect Genet Evol. 2017; 48:71-75, Impact Factor:3.5. (*Co-Corresponding author).
  8. Chakraborty S, Roy S, Mistry HU, Murthy S, George N, Bhandari V* and Sharma P*(senior authors). Potential Sabotage of Host Cell Physiology by Apicomplexan Parasites for Their Survival Benefits. Front. Immunol. 2017: 8:1261, Impact Factor: 6.43.
  9. Vasundhra Bhandari#, Shalini Chakraborty, Umarani Brahma. (#corresponding author). Identification of Anti-Staphylococcal and Anti-Biofilm Compounds from the Pathogen Box. Front Cell Infect Microbiol. Impact Factor: 4.3.
  10. Bhandari V, Sundar S, Dujardin JC, Salotra P. Elucidation of cellular mechanisms involved in experimental paromomycin resistance in Leishmania donovani. Antimicrob. Agents. Chemother. 2014; 58(5):2580-5, Impact Factor:4.7.
  11. Vasundhra Bhandari, Dhiraj Kumar, Sandeep Verma, G Srividya, NS Negi, Ruchi Singh, Poonam Salotra. Increased parasite surface antigen-2 expression in clinical isolates of Leishmania donovani augments antimony resistance. Biochem Biophys Res Commun. 2013; 440(4):646-51, Impact Factor: 2.53.
  12. Bhandari V, Kulshrestha A, Deep DK, Stark O, Prajapati VK, Ramesh V, Sundar S, Schonian G, Dujardin JC, Salotra P. Drug susceptibility in Leishmania isolates following miltefosine treatment in cases of visceral leishmaniasis and post kala-azar dermal leishmaniasis. PLoS Negl Trop Dis. 2012; 6(5):e1657, Impact Factor: 4.5.
  13. George N*, Bhandari V*, Reddy DP, Sharma P. Molecular and Phylogenetic analysis revealed new genotypes of Theileria annulata parasites from India. Parasit Vectors. 2015; 8:468. (* Shared Authorship), Impact Factor: 2.9.
  14. George N*, Bhandari V*, Reddy DP, Sharma P. Emergence of new genotype and diversity of Theileria orientalis parasites from bovines in India. Infect Genet Evol. 2015; 36:27-34. (* Shared Authorship), Impact Factor: 3.5.
  15. Gajanand Mittal, Vasundhra Bhandari*, Rajni Gaind#1, Vandana Rani1, Shimpi Chopra1, Reetika Dawar3, Raman Sardana3, PK Verma. Linezolid resistant Coagulase negative Staphylococci (LRCoNS) with novel mutations causing Blood stream Infections (BSI) in India (*Shared First Author). BMC Infectious Disease). Impact Factor: 2.9.
  16. Sonti Roy, Vasundhra Bhandari, Madhumanti Barman, Pankaj Kumar, Vandna Bhanot, Jaspreet Singh Arora, Satparkash Singh, Paresh Sharma. Population Genetic Analysis of the Theileria annulata Parasites Identified Limited Diversity and Multiplicity of Infection in the Vaccine From India. Frontiers in microbiology, 2021.Impact factor:4.2
  17. Rajesh, Sonti; Bhandari, Vasundhra; Dandasena, Debabrata; Murthy, Shweta; Sharma, Paresh; Genetic profiling reveals high allelic diversity, heterozygosity and antigenic diversity in the clinical isolates of the Theileria annulata from India. Frontiers in Physiology, 2019; 10:673. Impact factor : 3.367
  18. Tripathy, Suryasnata; Bhandari, Vasundhra; Sharma, Paresh; Vanjari, Siva Rama Krishna; Singh, Shiv Govind; Chemiresistive DNA hybridization sensor with electrospun nanofibers: A method to minimize inter-device variability. Biosensors and Bioelectronics, 2019; 133:24-31 Impact Factor : 10.1
  19. Dandasena D*, Bhandari V, Sreenivasamurthy GS, Murthy S, Roy S, Bhanot V, Arora J, Singh S, Sharma P. A Real-Time PCR based assay for determining parasite to host ratio and parasitaemia in the clinical samples of Bovine Theileriosis. Scientific Reports, 2018. Impact Factor: 4.259. [Accepted for Publication]
  20. Praveen Chapala; Adduru Jyothirmayi; Vasundhra Bhandari; Joydip Joardar, Swati Acharyya (2018). Effect of alloying elements on the microstructure, coefficient of friction, in-vitro corrosion and antibacterial nature of selected Ti-Nb alloys. Applied Surface Science Impact Factor: 4.4. [Accepted for Publication].
  21. Bahubali VH, Vijayan P, Bhandari V, Siddaiah N, Srinivas D. Methicillin Resistant Staphylococcus aureus intracranial abscess- an analytical series and review on molecular, surgical and medical aspects. Indian Journal of Medical Microbiology, 36: 97-103, 2018.
  22. Verma A, Bhandari V, Deep DK, Sundar S, Dujardin JC, Singh R, Salotra P. Transcriptome profiling identifies genes/pathways associated with experimental resistance to paromomycin in Leishmania donovani. Int J Parasitol Drugs Drug Resist. 2017; 7(3):370-377, Impact Factor: 4.8.
  23. Deep DK, Singh R, Bhandari V, Verma A, Sharma V, Wajid S, Sundar S, Ramesh V, Dujardin JC, Salotra P. Increased miltefosine tolerance in clinical isolates of Leishmania donovani is associated with reduced drug accumulation, increased infectivity and resistance to oxidative stress. PLoS Negl Trop Dis. 2017; 11(6):e0005641, Impact Factor: 4.5.
  24. Dawar R, Ganjoo A, Imdadi F, Bhandari V Multidrug Resistant Invasive Nontyphoidal Salmonella Isolated from and Masquerading Healed Tubercular Constrictive Pericarditis and Study of Virulence Markers. Cureus. 2017; 9(4):e1198.
  25. Hendrickx S, Inocêncio da Luz RA$, Bhandari V, Kuypers K, Shaw CD, Lonchamp J, Salotra P, Carter K, Sundar S, Rijal S, Dujardin JC, Cos P, Maes L. Experimental induction of paromomycin resistance in antimony-resistant strains of L. donovani: outcome dependent on in vitro selection protocol. PLoS Negl Trop Dis. 2012; 6(5):e1664 ($Authors Contributed Equally), Impact Factor: 4.5.
  26. Kulshrestha A, Bhandari V, Mukhopadhyay R, V. Ramesh, Sundar S, Maes L, Dujardin J C, Roy S, Salotra P. Validation of a simple resazurin based promastigote assay for the routine monitoring of Miltefosine susceptibility in clinical isolates of Leishmania donovani. Parasitol Res. 2013; 112:825-828, Impact Factor: 2.9.
  27. Verma S, Bhandari V, Avishek K, Ramesh V, Salotra P. Reliable diagnosis of Post Kala-azar Dermal Leishmaniasis (PKDL) using slit aspirate specimen to avoid invasive sampling procedures. Trop Med Int Health. 2013; 18(3):268-75, Impact Factor: 2.85.
  28. Kumar D$, Singh R$, Bhandari V, Kulshrestha A, Negi NS, Salotra P ($ Authors Contributed Equally). Biomarkers of antimony resistance: need for expression analysis of multiple genes to distinguish resistance phenotype in clinical isolates of Leishmania donovani. Parasitol Res. 2012; 111(1): 223-30, Impact Factor: 2.9.
  29. Subba Raju BV, Gurumurthy S, Kuhls K, Bhandari V, Schnonian G, Salotra P. Genetic typing reveals monomorphism between antimony sensitive and resistant Leishmania donovani isolates from visceral leishmaniasis or post kala-azar dermal leishmaniasis cases in India. Parasitol Res. 2012; 111(4): 1559-68, Impact Factor: 2.9.



PATENTS

One Patent Filed



INVITED TALKS

  1. Invited presenter in Lab steering committee meeting of European project Kaladrug-R held at Kathmandu, Nepal from 23-25th Sep, 2012.
  2. Invited and presented work in Lab steering committee meeting at Strathclyde University, Glasgow, UK in June, 2011.



LABORATORY FACILITIES DEVELOPED

Under development



ADDITIONAL RESPONSIBILITIES

NIL



ANY OTHER INFORMATION

The lab is currently open for the research scholars at different levels eg., RA, SRF, JRF etc.).
An applicant with their own fellowship and interested to work in our lab can please contact the PI for PhD.