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Name: Dr. S. GananadhamuAssistant Professor  gana.niperhyd@gov.in +91 40 23074750 Extn- 2013 +91-040-23074750 (Ext. No: 2013)
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ADDRESS, ROOM NO 
Department of Pharmaceutical Analysis
Room no: 48
NIPER Hyderabad
Balanagar, Hyderabad-500037, TS, INDIA
QUALIFICATION: (REVERSE CHRONOLOGICAL ORDER)
Ph.D (Andhra University),
M.Pharm (Andhra University) and
B.Pharm (Acharya Nagarjuna University)
EXPERIENCE
Currently working as assistant professor at NIPER, Hyderabad since
2009. 3 years and 9 months as a senior lecturer at at K.V.S.R. Siddhartha
College of Pharmaceutical Sciences, Vijayawada (December 2005 to
August 2009). 2 years and 3 months as a scientist-II at Torrent Research Centre,
Village-Bhatt, Gandhinagar, Gujarat (September 2003 to November
2005).
COURSES HANDLING(PHD/M.PHARM) M.S (Pharm):
Topics in Pharmaceutical Analysis (PA-510)
Quality Control and Quality Assurance (PA-610)
Pharmacopeial Methods of Analysis (PA-640)
Ph.D:
Method Development and Trouble Shooting of GC and HPLC (PA-720)
Analytical Chemometrics (PA-750)
PHD STUDENTS/MASTERS STUDENTS
Masters: Submitted -9 [Advisor] + 28 [Joint Advisor]
Ongoing - 1 [Advisor] + 4 [Joint Advisor]
Ph.D: Submitted -1 [Advisor] + 1 [Joint Advisor]
Ongoing - 3 [Advisor]
AWARDS / HONOURS APP (Association of Pharmaceutical Professionals) young talent award
2016 (2016)Associate fellow of Telangana Academy of Sciences (2016) 
RESEARCH AREAS/INTEREST Study of drug degradation chemistry and drug stability testing Impurity profiling of drugs Bioanalytical method development and metabolite profiling Development of new analytical methods for detecting the counterfeit
of drugs Analytical method development for release testing of active
pharmaceutical ingredients and pharmaceutical formulations Preformulation studies Standardization of herbal drugs 
PUBLICATIONS / BOOK CHAPTERS 1) S. Gananadhamu.; Debasish Swain.; Gayatri Sahu.; Shweta Bhagat.; P.V.
Bharatam. Ultra HPLC Method for Fixed Dose Combination of Azilsartan
Medoxomil and Chlorthalidone: Identification and in silico Toxicity
Prediction of Degradation Products, Journal of Analytical Chemistry, 2018,
73 (6), 560-569.
2) M. Thummar.; Debasish Swain.; S. Gananadhamu. Separation and
Characterization of New Forced Degradation Products of Macitentan: A
Dual Endothelin Receptor Antagonist, Chromatographia, 2018, 81, 525–
531.
3) M. Thummar.; P. N. Patel.; S. Gananadhamu.; R. Srinivas. Stability
indicating assay method for acotiamide: separation, identification and
characterization of its hydroxylated and hydrolytic degradation products
along with a process related impurity by UHPLC‐ESI‐QTOF‐MS/MS, Rapid
communications in mass spectrometry, 2017, 31, 1813-1824.
4) P. N. Patel.; P. D. Kalariya.; M. Thummar.; S. Gananadhamu.; R. Srinivas.
In vivo metabolite identification of acotiamide in rats using
ultra‐performance liquid chromatography‐quadrupole/time‐of‐flight mass
spectrometry, Biomedical Chromatography, 2017 (In-press)
5) Pradipbhai D. Kalariya.; Deepak, N.; Srinivas, R.; Gananadhamu, S.
Application of experimental design and response surface technique for
selecting the optimum RP-HPLC conditions for the determination of
moxifloxacin HCl and ketorolac tromethamine in eye drops. Journal of
Saudi Chemical Society, 2017, 71, S373-S382.
6) Mohit Thummar.; Prinesh N. Patel.; Arun L. Petkar.; Debasish Swain.; R.
Srinivas.; Gananadhamu Samanthula. Identification of degradation
products of saquinavir mesylate by ultra‐high‐performance liquid
chromatography/electrospray ionization quadrupole time‐of‐flight tandem
mass spectrometry and its application to quality control, Rapid
communications in mass spectrometry, 2017, 31, 771-781.
7) Debasish Swain.; Gananadhamu Samanthula. Study on the forced
degradation behaviour of ledipasvir: Identification of major degradation
products using LC–QTOF–MS/MS and NMR, Journal of Pharmaceutical
and Biomedical Analysis, 2017,138, 29-42.
8) Vishnuvardhan C, Saibaba B, Allakonda L, Swain D, Gananadhamu S,
Srinivas R, Satheeshkumar N; LC-ESI-MS/MS evaluation of forced
degradation behaviour of silodosin: In vitro anti cancer activity evaluation
of silodosin and major degradation products. J Pharm Biomed Anal. ,
2017, 134, 1-10.
9) Chiguru Vishnuvardhan, Debasish Swain, Roshan Borkar, S.
Gananadhamu, R. Srinivas, N. Satheeshkumar.; Study of forced
degradation behaviour of brinzolamide using LC-ESI- Q-TOF and in silico
toxicity prediction. Chromatographia, 2016, 79, 1293.
10) Prinesh N. Patel.; Pradipbhai D. Kalariya.; Swamy C.V.; Gananadhamu S.;
Srinivas R. Quantitation of acotiamide in rat plasma by UHPLC-Q-TOF-MS:
method development, validation and application to pharmacokinetics.
Biomed Chromatogr. 2016, 30, 363-368.
11) Debasish Swain.; Prinesh N Patel.; Gangam Nagaraj.; Kona S Srinivas.;
Mahesh Sharma.; Prabha Garg.; Gananadhamu Samanthula. Liquid
Chromatographic Method Development for Forced Degradation Products
of Dabigatran Etexilate: Characterisation and In Silico Toxicity Evaluation.
Chromatographia. 2016, 79, 169-178.
12) Debasish Swain.; Gananadhamu Samanthula.; Shweta Bhagat.; P.V.
Bharatam.; Venkatakrishna Akula.; Barij N. Sinha. Characterization of forced
degradation products and in silico toxicity prediction of Sofosbuvir: A
novel HCV NS5B polymerase inhibitor. J. Pharm. Biomed. Anal. 2016, 120,
352-363.
13) Prinesh N. Patel.; Vijaya Saradhi Karakam.; Gananadhamu S.; Srinivas R.
Quality-by-design-based ultra high performance liquid chromatography
related substances method development by establishing the proficient
design space for sumatriptan and naproxen combination. J. Sep. Sci. 2015,
38(19), 3354-62.
14) Swain D.; Sahu G.; Samanthula G. Rapid LC-MS compatible stability
indicating assay method for azilsartan medoxomil potassium. J. Anal.
Bioanal. Tech. 2015, 6, 254.
15) Prinesh N. Patel.; Pradipbhai D. Kalariya.; Gananadhamu S.; Srinivas R.
Forced degradation of fingolimod: Effect of co-solvent and
characterization of degradation products by UHPLC-Q-TOF–MS/MS and
1H NMR. J. Pharm. Biomed. Anal. 2015, 115, 388-394.
16) Debasish Swain.; Prinesh N. Patel.; Ilayaraja Palaniappan.; Gayatri
Sahu.; Gananadhamu Samanthula. Liquid Chromatography-Tandem Mass
Spectrometry Study of Forced Degradation of Azilsartan Medoxomil
Potassium. Rapid Commun. Mass spectrom, 2015, 29, 1437–1447.
17) Prinesh N. Patel.; Pradipbhai D. Kalariya.; Mahesh Sharma.; Prabha
Garg.; M. V. N Kumar Talluri.; Gananadhamu Samanthula.; Srinivas
Ragampeta. Characterization of forced degradation products of pazopanib
hydrochloride by UHPLC-Q-TOF/MS and in silico toxicity prediction, J.
Mass Spectrom. 2015, 50, 918–928.
18) Prinesh N. Patel.; D. Rajesh Kumar.; S. Gananadhamu.; R. Srinivas.
Characterization of the stress degradation products of tolvaptan by UPLCQ-TOF-MS/MS,
RSC Adv., 2015, 5, 21142-21152.
19) Prinesh N. Patel.; Roshan M. Borkar.; Pradipbhai D. Kalariya.; Rahul P.
Gangwal.; Abhay T. Sangamwar.; Gananadhamu Samanthula.; Srinivas
Ragampeta. Characterization of degradation products of Ivabradine by LCHR-MS/MS:
a typical case of exhibition of different degradation behaviour
in HCl and H2SO4 acid hydrolysis, J. Mass Spectrom. 2015, 50, 344–353.
20) Samanthula, G.; Shrigod, V. V.; Patel, P. N. Validated Stability-Indicating
Assay Method for Simultaneous Determination of Aceclofenac and
Thiocolchicoside using RP-HPLC, Drug Research. 2014, 64, 429-435.
21) Pradipbhai D. Kalariya, B. Raju, Roshan M. Borkar, Deepak Namdev, S.
Gananadhamu, Prajwal P. Nandekar, Abhay T. Sangamwar, R. Srinivas.
Characterization of forced degradation products of ketorolac
tromethamine using LC/ESI/Q/TOF/MS/MS and in silico toxicity prediction,
J. Mass Spectrom. 2014, 49, 380–391.
22) Deepak, N.; Roshan, M. B.; Raju, B.; Pradipbhai, D. K.; Vinodkumar, T. R.;
Gananadhamu, S.; Srinivas, R. Identification of forced degradation
products of Tamsulosin using liquid chromatography/electrospray
ionization tandem mass spectrometry. J. Pharm. Biomed. Anal. 2014, 88,
245-255.
23) Prinesh N. Patel.; Gananadhamu Samanthula.; Veeraraghavan
Sridhar.; Rambabu Arla.; Kanthi Kiran V. S. Varanasi.; Swaroop Kumar
V.V.S. Validated LC-MS/MS method for simultaneous determination of
Dasatinib and Sitagliptin in rat plasma and its application to
pharmacokinetic study, Anal. Methods. 2014, 6, 433-439.
24) Prinesh, N.P.; Gananadhamu, S.; Vishalkumar, S.; Sudipkumar, C. M.;
Jainishkumar, R. C. RP-HPLC method for determination of several NSAIDs
and their combination drugs. Chromatography Research International,
2013, 2013, 13.
25) Gananadhamu, S.; Krishnaveni, Y.; Shantikumar, S.; Sreekanth, G.;
Surendranath, K. V. Stability-Indicating RP-HPLC Method for Simultaneous
Estimation of Doxophylline and Terbutalinesulphate in Pharmaceutical
Formulations. Sci. Pharm. 2013, 81, 969–982.
26) Gananadhamu, S.; Laxmikanth, V.; Shantikumar, S; Sridhar, V; Geetha,
C; Sandhya, C. Rapid LC-ESI-MS-MS Method for the Simultaneous
Determination of Sitagliptin and Pioglitazone in Rat Plasma and Its
Application to Pharmacokinetic Study. American Journal of Analytical
Chemistry. 2012, 3, 849-858.
27) Ramakrishna Y.; Mohd. M.; Ramakrishna B.; Gananadhamu, S.
Development and Validation of a New RP-HPLC Method for the
Estimation of Valsartan and Hydrochlorothiazide in Tablets, IJPI’s Journal
of Analytical Chemistry. 2012, 2(8), 13-19.
28) Santhi, N.; Deepthi, Ch.; Rajendran, S.S.; Gananadhamu, S.; Devala Rao,
G.; Sai, L. Spectrophotometric estimation of Ziprasidone in bulk and in
Pharmaceutical formulations. Asian Journal of Pharmaceutical Analysis,
2011, 1(1), 08-09.
29) Ravisankar, P.; Deva Dasu, Ch.; Srinivasa Babu, P.; Devala Rao, G.;
Gananadhamu, S. Development and Validation of New RP-HPLC Method
for the Estimation of Prulifloxacin in Pharmaceutical Dosage Forms.
International Journal of Chemical Sciences, 2010, 8(1), 433-444.
30) Sastry, B.S.; Gananadhamu, S.; Prasad, S.V.S.G.B.; Venu Gopala Raju, K.
New spectrophotometric methods for the estimation of Lenalidomide in
pharmaceutical formulations. Journal of Pharma Tech Research, 2009, 1(3),
416-419.
31) Gananadhamu, S.; Sastry, B. S.; Devala Rao, G. RP-HPLC determination
of aripiprazole in pharmaceutical formulations. Asian journal of chemistry,
2009, 21(9), 6643-6646.
32) Sastry, B. S.; Gananadhamu, S.; Devala Rao, G. Estimation of
Aripiprazole in pharmaceutical formulations by spectrophotometry. Acta
Ciencia Indica, 2008, 34C (4), 631.
33) Gananadhamu, S.; Sastry, B. S.; Devala Rao, G. Development of RPHPLC
Method for estimation of Drotaverine Hydrochloride in
pharmaceutical formulations. International Journal of Chemical Sciences,
2008, 6(4), 2055-2061.
34) Sastry, B.S.; Gananadhamu, S.; Devadasu, Ch.; Balaji, K. New RP-HPLC
Method for estimation of Donepezil hydrochloride in pharmaceutical
formulations. International Journal of Chemical Sciences, 2008, 6(4), 1976-
1983.
35) Krishna, P.; Devala Rao, G.; Gananadhamu, S. Development of HPLC
method for the determination of Zaleplon in pharmaceutical formulations.
Acta Ciencia Indica, 2008, 34 C, 4, 623.
36) Elayaraja, A.; Rahaman, S. A.; Gananadhamu, S.; Devala Rao, G.
Antibacterial Activity of Various Crude Extracts of Justicia tranquebariensis.
Journal of pure and applied microbiology, 2008, 2(1) Page No. 231-233.
37) Sastry, B. S.; Gananadhamu, S.; Devala Rao, G. Visible
spectrophotometric methods for estimation of Aripiprazole in
pharmaceutical formulations. International Journal of Chemical Sciences,
2007, 5(5), 2197-2202.
38) Gananadhamu, S.; Sastry, B. S.; Devala Rao, G. Extractive
spectrophotometric determination of Donepezil hydrochloride.
International Journal of Chemical Sciences, 2007, 5(3), 1150-1154.
39) Sastry, B. S.; Gananadhamu, S.; Devala Rao, G. New spectrophotometric
methods for estimation of Donepezil hydrochloride in pharmaceutical
formulations. Acta Ciencia Indica, 2007, 33C (4), 411.
40) Sastry, B. S.; Gananadhamu, S.; Devala Rao, G. 2,4-DNPH: A
chromogenic reagent for estimation of Donepezil hydrochloride in
pharmaceutical formulations. Journal of Pharmaceutical research, 2007,
6(3), 176-177.
41) Gananadhamu, S.; Sastry, B. S.; Devala Rao, G. Extractive
spectrophotometric determination of Drotaverine hydrochloride in
pharmaceutical formulations. Acta Ciencia Indica, 2006, 32C (3), 331.
PATENTS 
INVITED TALKS
1) “UHPLC: A Green chromatographic technique” at a conference on “New
horizons of green synthetic and analytical techniques” organized by
K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Vijayawada on
23rd September 2017.
2) “Practical conduct of impurity profiling” at a workshop on “Hands-on
training, troubleshooting, method development and validation techniques
in HPLC and UPLC” conducted by Spectrum pharma research solutions,
Hyderabad on 3rd September 2017.
3) “Identification of drug degradation products by using high resolution
mass spectrometry” at “PHARMA NIPUNA – 2017” conference by
Venkateshwara Institute of Pharmaceutical Sciences, Charlapally, Nalgonda
on 1st April 2017.
4) “Impurity profiling of pharmaceuticals” at 2nd Indo-Korean conference
on “Herbals and Pharmaceuticals: Pivotal Issues and Concerns” conducted
at Gokula Krishna College of Pharmacy, Sullurpeta on 30th March 2016.
5) “GC-MS method development” at Quality Improvement Programme for
Faculty conducted by University College of Pharmaceutical Sciences,
Kakatiya University, Warangal on 1st November 2014.
6) “Role of Modern Instrumentation Techniques In Current Concepts
of Pharmaceutical Sciences” at the UGC sponsored National Workshop
was organized at ANU College of Pharmaceutical Sciences, Guntur on 14th
March 2014.
ADDITIONAL RESPONSIBILITIES Additional controller of examinations
