Dept. of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India
logo
logo
logo
Menu

logo

HOME/FACULTY& STAFF/ PROFILE

Pharmaceutical Analysis Department >
Dr. Amit Asthana >
Dr. S. Gananadhamu >
Dr. Rajesh Sonti >
Dr. Amol G. Dikundwar >

Faculty Profile : Dr. Amol G. Dikundwar

Name: Dr. Amol G. Dikundwar


Assistant Professor
amol.dikundwar@niperhyd.ac.in
+91 40 23074750 Extn- 2035
+91-040-23074750 (Ext. No: 2036)
Citations Link


ADDRESS, ROOM NO

Department of Pharmaceutical Analysis
Room no: 05
NIPER Hyderabad
Balanagar, Hyderabad-500037, TS, INDIA



QUALIFICATION: (REVERSE CHRONOLOGICAL ORDER)

Doctor of Philosophy (Ph.D.)

Institute: Solid state and Structural Chemistry Unit, Indian Institute of Science, Bangalore, India [2008-2013]
Dissertation: Organic Flourine in Crystal engineering: Consequences at Molecular and Supramolecular level. (Thesis advisor: Professor T. N. Guru Row; worked with Prof. G. R. Desiraju on collaborative projects)
Research areas: In situ cryocrystallography, crystal engineering and polymorphism, charge density analysis, neutron diffraction, powder diffraction

Master of Science (M.Sc.)

Institute: Department of Chemistry, RTM Nagpur University, Nagpur, India [2005-2007] (First division)
Specialization: Organic chemistry with Medicinal chemistry as optional credits

Bachelor of Science (B.Sc.)

Institute: Lokmanya Tilak Mahavidyalaya, Wani, SGB Amaravati University, Amaravati, India [2002-2005] (Distinction)
Specialization: Major Subjects: Physics, Chemistry and Mathematics


EXPERIENCE

  • Assistant Professor, January 2021 - Till date at NIPER, Hyderabad, India

  • Principal Investigator (Apr 2018 - Jan 2021) at Analytical Research & Development, Biocon Bristol-Myers Squibb Research and Development Center, Syngene International Limited, Bangalore, India
    Role: Leading solid state characterization, small molecule crystallography and IR/Raman PAT teams, Matrix leader for Material Selection and Development Team, Member of extended leadership team in the organization

  • Senior Research Investigator (Jan 2016 - Mar 2018) at Analytical Research & Development, Biocon Bristol-Myers Squibb Research and Development Center, Syngene International Limited, Bangalore, India
    Role: Team leader for solid state characterization and small molecule crystallography team

  • Research Investigator (Sep 2013 - Dec 2015) at Biopharmaceutics, Biocon Bristol-Myers Squibb Research and Development Center, Syngene International Limited, Bangalore, India
    Role: Crystallography support to discovery and development projects



COURSES HANDLING(PHD/M.PHARM)

  • PA-620: Modern Instrumental Techniques for Evaluation of APIs and Drug Products
  • PE-660: Solid State Pharmaceutics
  • MC-630: ‘Biological crystallography’ and ‘Thermodynamical methods’ chapters
  • GE-611: Seminar
  • LS-610: General Lab Experience



PHD STUDENTS/MASTERS STUDENTS

Ph.D: 01 (ongoing) - Nagesh Bhale


AWARDS / HONOURS
  • Poster prize at Applied Pharmaceutical Analysis conference (APA-India 2020) at Ahmedabad, India
  • “BMS Bravo Award-2018” for establishing PoC of using existing small molecule crystallography set up for protein data collection
  • “Excellence Award-2018” for successful in-house transition of a molecule across various stages of drug development
  • First position (team Soch) in case study analysis and presentation competition on “Diversity and Inclusion”, 2017
  • “Galaxy Award-2016” for successful completion of lead optimization for Allied Bristol-Myers Squibb Life Sciences (ABLS-02) program
  • “BMS Star Award-2015” for organising and conducting a short course (20 hours) ‘Polymorphism and Crystallization in Pharmaceuticals’ for fellow scientists within PD organization
  • “CCDC Poster Prize” in the 22nd IUCr general assembly, Madrid, Spain for the presentation of the poster entitled “‘Organic’ Fluorine Dictates the Molecular Conformation and Packing” in August 2011
  • “IUCr Best Poster Award” in the ICCOSSXX, Bangalore, India for the presentation of the poster entitled “Structural Variability in the Monofluorophenylacetylenes Mediated through Interactions Involving ‘Organic’ Fluorine” in June 2011
  • Qualified National Eligibility Test (NET-2007, JRF) and Graduate Aptitude Test Examination (GATE-2008, percentile 98.88)
  • National Cadet Corps (NCC) A, B and C certificates
  • Member of Indian Crystallography Association and Marathi Vidhyan Parishad, Mumbai
  • Member of International Center for Diffraction Data (ICDD)


RESEARCH AREAS/INTEREST
  • Materials Science and Engineering: Form screening, determination of relative stabilities of polymorphs, providing inputs for generation of stable or relevant forms on scale and risk mitigation for occurrence of undesired forms
  • Formulation and Biopharmaceutical risk assessment aspects in API form selection, form enablement using salt/SDD options and development Oral Solid Dosage forms
  • Accelerated ss stability studies for drug substance, drug product intermediates and drug products
  • Crystallization process development and particle engineering aspects such as controlling particle shape/size, size reduction by milling, etc. and associated analyses such as optical microscopy and particle size/shape analysis
  • Materials Characterization: common bulk analytical techniques e.g. PXRD, DSC, TGA, KF, DVS, etc. for form characterization (neat, solvate, hydrate, etc.) and understanding form relationship/transformations (enantiotropy, monotropy, etc.)
  • Advanced analyses (indexing, profile fitting, ab initio structure determination) and amorphous characterization (TS-PDF) using high resolution powder diffraction
  • Small Molecule Crystallography: Structure elucidation using single crystal X-ray diffraction, Crystallographic computations and quantum chemical calculations, Experimental and theoretical charge density analysis to understand fine details of molecular and supramolecular properties, Prediction, correlation of physicochemical properties by detailed analysis of crystal structure of API and related molecules from Crystal Structure Database
  • Method development and validation of solid state analytical methods


FELLOWSHIPS / GRANTS
  • Awarded Junior Research Fellowship (2008-2010) and Senior Research Fellowship (2010-2013) by Ministry of HRD, Government of India, India
  • Several travel grants for attending international conferences, synchrotron data collection (Elletra, Italy), neutron data collection (ANSTO, Australia).

PUBLICATIONS / BOOK CHAPTERS

  1. R. K. Pathak, A. G. Dikundwar, T. N. Guru Row and C. P. Rao, A lower rim triazole linked calix[4]arene conjugate as a fluorescence switch on sensor for Zn2+ in blood serum milieu, Chem. Commun., 2010, 46, 4345-4347 (Communication).
  2. C. M. Zade, U. D. Pete, A. G. Dikundwar and R. S. Bendre, (Z)-2-(2-Isopropyl-5-methylphenoxy)-N'-(2-oxoindolin-3-ylidene)acetohydrazide, Acta Cryst., 2010, E66, o1614.
  3. K. R. Prasad, A. Chandrakumar, A. G. Dikundwar and T. N. Guru Row, Polymorphism in a TADDOL analogue induced by the presence of a chiral impurity, CrystEngComm, 2010, 12, 3452-3454 (Communication).
  4. T. S. Thakur, R. Sathishkumar, A. G. Dikundwar, T. N. Guru Row, and G. R. Desiraju, Third Polymorph of Phenylacetylene, Crystal Growth & Design, 2010, 10, 4246-4249 (Communication).
  5. A. G. Dikundwar, C. Venkateswarlu, R. O. Piltz, S. Chandrasekaran and T. N. Guru Row, Crystal structures of fluorinated aryl biscarbonates and a biscarbamate: a counterpoise between weak intermolecular interactions and molecular symmetry, CrystEngComm, 2011, 13, 1531-1538.
  6. A. Bandela, J. P. Chinta, V. K. Hinge, A. G. Dikundwar, T. N. Guru Row, and C. P. Rao, Recognition of Polycyclic Aromatic Hydrocarbons and Their Derivatives by the 1,3-Dinaphthalimide Conjugate of Calix[4]arene: Emission, Absorption, Crystal Structures, and Computational Studies, J. Org. Chem., 2011, 76, 1742-1750.
  7. M. N. Manjunatha, A. G. Dikundwar, and K. R. Nagasundara, Zn(II), Cd(II) and Hg(II) complexes with 1-(p-methoxybenzyl)-2-(p methoxyphenyl)benzimidazole: Syntheses, structures and luminescence, Polyhedron, 2011, 30, 1299-1304.
  8. A. G. Dikundwar, G. K. Dutta, T. N. Guru Row, and S. Patil, Polymorphism in Opto-Electronic Materials with a Benzothiazole-fluorene Core: A Consequence of High Conformational Flexibility of π-Conjugated Backbone and Alkyl Side Chains, Crystal Growth & Design, 2011, 11, 1615-1622.
  9. S. S. Wazalwar, N. S. Bhave, A. G. Dikundwar and P. Ali, Microwave Assisted Synthesis and Antimicrobial Study of Schiff Base Vanadium(IV) Complexes of Phenyl Esters of Amino Acids, Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry, 2011, 41, 459-464.
  10. R. S. Sancheti, A. G. Dikundwar and R. S. Bendre, 2-{[{2-Hydroxy-3-[2-methyl-5-(propan-2-yl)phenoxy]propyl}(pyridin-2-ylmethyl)amino]methyl}phenol, Acta Cryst., 2011, E67, o1605.
  11. A. G. Dikundwar, R. Sathishkumar, T. N. Guru Row, and G. R. Desiraju, Structural Variability in the Monofluoroethynylbenzenes Mediated through Interactions Involving “Organic” Fluorine, Crystal Growth & Design, 2011, 11, 3954-3963.
  12. A. G. Dikundwar and T. N. Guru Row, Evidence for the “Amphoteric” Nature of Fluorine in Halogen Bonds: An Instance of Cl…F Contact, Crystal Growth & Design, 2012, 12, 1713-1716 (Communication).
  13. S. Aitipamula, R. Banerjee, A. K. Bansal, K. Biradha, M. L. Cheney, A. R. Choudhury, G. R. Desiraju, A. G. Dikundwar, R. Dubey, N. Duggirala, P. P. Ghogale, S. Ghosh, P. K. Goswami, N. R. Goud, R. K. R. Jetti, P. Karpinski, P. Kaushik, D. Kumar, V. Kumar, B. Moulton, A. Mukherjee, G. Mukherjee, A. S. Myerson, V. Puri, A. Ramanan, T. Rajamannar, C. M. Reddy, N. Rodriguez-Hornedo, R. D. Rogers, T. N. Guru Row, P. Sanphui, N. Shan, G. Shete, A. Singh, C. C. Sun, J. A. Swift, R. Thaimattam, T. S. Thakur, R. K. Thaper, S. P. Thomas, S. Tothadi, V. R. Vangala, P. Vishweshwar, D. R. Weyna, and M. J. Zaworotko, Polymorphs, Salts, and Cocrystals: What’s in a Name?, Crystal Growth & Design, 2012, 12, 2147-2152 (Perspective).
  14. U. D. Pete, C. M. Zade, J. D. Bhosale, S. G. Tupe, P. M. Chaudhary, A. G. Dikundwar, R. S. Bendre, Hybrid Molecules of Carvacrol and Benzoyl Urea/Thiourea with Potential Applications in Agriculture and Medicine, Bioorg. Med. Chem. Lett., 2012, 22, 5550-5554.
  15. A. G. Dikundwar, U. D. Pete, C. M. Zade, R. S. Bendre and T. N. Guru Row, Tracing a common ‘Origin’ of Phase Transformation, Polymorphism, Disorder, Isosterism and Isostructuralism in Fluorobenzoylcarvacryl Thiourea, Crystal Growth & Design, 2012, 12, 4530-4534.
  16. S. R. Shah, S. S. Navathe, A. G. Dikundwar, T. N. Guru Row, and A. T. Vasella, Thermal Rearrangement of Azido Ketones into Oxazoles via Azirines: One-Pot, Metal-Free Heteroannulation to Functionalized 1,3-Oxazoles, Eur. J. Org. Chem., 2013, 2013, 264-267.
  17. A. G. Dikundwar, C. Venkateswarlu, R. N. Chandrakala, S. Chandrasekaran and T. N. Guru Row, H/F Isosteric Substitution to attest Different Equi-energetic Molecular Conformations in Crystals, CrystEngComm, 2013, 15, 5403-5406 (Communication).
  18. A. G. Dikundwar, R. Sathishkumar and T. N. Guru Row, Fluorine prefers hydrogen bonds over halogen bonds! Insights from crystal structures of some halofluorobenzenes, Zeitschrift für Kristallographie - Crystalline Materials, 2014, 229, 609-624 (Invited article).
  19. A. G. Dikundwar and T. N. Guru Row, Tracing a Crystallization Pathway of an RT Liquid, 4-Fluorobenzoyl Chloride: Metastable Polytypic Form as an Intermediate Phase, Crystal Growth & Design, 2014, 14, 4230–4235 (Communication).
  20. U. D. Pete, A. G. Dikundwar, V. M. Sharma, S. P. Gejji, R. S. Bendre and T. N. Guru Row, Partial rotation of the isopropyl group in the solid state: single-crystal-to-single-crystal phase transformation in a carvacrol derivative, CrystEngComm, 2015, 17, 7482-7485 (Communication).
  21. A. G. Dikundwar, P. Chodon, S. P. Thomas, H. Bhutani, Supramolecular Chemistry of BrettPhos and BrettPhos Oxide: Breakup of Isostructurality via Order-Disorder Phase Transitions, Crystal Growth & Design, 2017, 17, 1982-1990.
  22. L. S. Harikrishnan, J. Warrier, A. J. Tebben, G. Tonukunuru, S. R. Madduri, V. Baligar, R. Mannoori, B. Seshadri, H. Rahaman, P. N. Arunachalam, A. G. Dikundwar, B. E. Fink, J. Fargnoli, M. Fereshteh, Y. Fan, J. Lippy, C. P. Ho, B. Wautlet, S. Sheriff, M. Ruzanov, R. M. Borzilleri, Heterobicyclic inhibitors of transforming growth factor beta receptor I (TGFβRI), Bioorg Med Chem, 2018, 26, 1026-1034.
  23. A. G. Dikundwar, S. Pal, P. Chodon, R. Narasimhamurthy, P. Kameshwar, M. Sundaram, H. Bhutani, Solid State Behavior of Impurities during "in-Process" Phase Purity Analysis of an API, Org. Process Res. Dev., 2019, 23, 269-273 (Communication).
  24. M. Sundaram, S. Natarajan, A. G. Dikundwar, H. Bhutani, Quantification of Solid-State Impurity with Powder X-ray Diffraction using Laboratory Source, Powder Diffraction, 2020, 35, 226-232.
  25. A. Karmakar, R. Y. Nimje, A. Silamkoti, M. Pitchai, M. Basha, C. Singarayer, D. Ramasamy, G. T. V. Babu, R. Samikannu, S. Subramaniam, P. Anjanappa, M. Vetrichelvan, H. Kumar, A. G. Dikundwar, A. Gupta, A. K. Gupta, R. Rampulla, T. G. M. Dhar and A. Mathur, A Practical Synthesis of (3aR, 9bR)-8-fluoro-7-(perfluoropropan-2-yl)-9b-(phenylsulfonyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole: An Advanced Intermediate to Access RORγt Inverse Agonist BMT-362265, Org. Process Res. Dev., 2021, 25, 4, 1001-1014.



PATENTS

NIL



INVITED TALKS

  1. “Applications of Crystallography in Pharmaceutical Sciences” in Crystallography Workshop conducted at M.S. Ramaiah Institute of Technology, Bangalore, July 2014
  2. “Detection and Quantification of Low Levels of Solid State Impurities by PXRD: A comparison with HPLC” at Workshop on PXRD in Pharmaceutical and Materials Industry (ICDD), Bangalore, India, June 2018
  3. “Solid Form Screening and Selection in Pharmaceutical Development: Implications on Materials Properties and Performance” in 46th National Seminar on Crystallography held at Bangalore, India, June 2018



SPONSORED PROJECTS

NIL

Laboratory facilities developed for research / teaching.

Analytical Testing Laboratory (Room No. 007 and 008)


ADDITIONAL RESPONSIBILITIES

In-charge: Analytical Testing Laboratory (Room No. 007 and 008)



ANY OTHER INFORMATION

NIL