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Publications in 2022

Publications are the primary method for reporting and long-term documentation of the research conducted at the NIPER-Hyderabad. Here the list of publications published in year wise...


  1. Rh(III)-catalysed site-selective alkylation of β-carbolines/isoquinolines and tandem C–H/C–N functionalization to construct indolizineindole frameworks; Bora, D.; John, S. E.; Galla, M. S.; Shankaraiah, N. Mol. Cat., 2022, 533, 112783
  2. Synthesis of alpha-pyrones and chromen-2-ones by transition-metal catalyzed annulations of sulfoxonium and iodonium ylides with cisstilbene acids; John, S. E.; Bora, D.; Dastari, S.; Valapil, D. G.; Shankaraiah, N. New J. Chem., 2022, 46, 19722–19730
  3. Catalyst-Free Site-Selective Diverse Functionalization of Inherent C–H Bonds in 1-Aryl-β-carbolines, Norharmane and Harmine; Soni, J. P.; Kumawat, A.; Sathish, M.; Yadav, S.; Jadhav, N. A.; Shankaraiah, N. ChemistrySelect 2022, 7, e202202299
  4. Ru(II)-Catalyzed regioselective carbene insertion into β-carbolines and isoquinolines; John, S. E.; Bora, D.; Shankaraiah, N. Org. Biomol. Chem. 2022, 20, 5852-5860 <\li>
  5. Design, synthesis of DNA-interactive 4-thiazolidinone-based indolo-/pyrroloazepinone conjugates as potential cytotoxic and topoisomerase I inhibitors; Kadagathur, M.; Patra, S.; Panda, B.; George, J.; Phanindranath, R.; Shaikh, A. S.; Sigalapalli, D. K.; Godugu, C.; Nagesh, N.; Tangellamudi, N. D.; Shankaraiah, N. Eur. J. Med. Chem. 2022, 238, 114465
  6. Brown seaweed-derived alginic acid: An efficient and reusable catalyst for Pictet-Spengler reaction to access tetrahydro-β-carboline and tetrahydroisoquinoline frameworks; Soni, J. P.; Sathish, M.; Nachtigall, F. M.; Santos, L. S.; Shankaraiah, N. Asian J. Org. Chem., 2022, 11, e202200129
  7. The Expedition of Azido-reductive Cyclization Approaches towards Various Heterocycles; Soni, J. P.; Jadhav, N.; Shankaraiah, N. Curr. Org. Chem., 2022, 26, 382-398
  8. The syntheses and medicinal attributes of phenanthrenes as anticancer agents: a quinquennial update; Jhingran, S.; Laxmikeshav, K.; Sayali, M.; Rao, K. V.; Shankaraiah, N. Curr. Med. Chem., 2022, 29, 3530–3556
  9. Contribution of Knoevenagel Condensation Products toward the Development of Anticancer Agents: An Updated Review; Tokala, R.; Bora, D.; Shankaraiah, N. ChemMedChem., 2022, 17, e202100736
  10. Exploration of Mercaptoacetamide-linked Pyrimidine-1,3,4-Oxadiazole Derivatives as DNA Intercalative Topo II inhibitors: Cytotoxicity and Apoptosis Induction; Shaikh, A. S.; Kiranmai, G.; Devi, G. P.; Makhal, P. N.; Sigalapalli, D. K.; Tokala, R.; Kaki, V. R.; Shankaraiah, N.; Nagesh, N.; Babu, B. N.; Tangellamudi, N. D. Bioorg. Med. Chem. Lett., 2022, 65, 128697
  11. Synthesis of indolo/pyrroloazepinone-oxindoles as potential cytotoxic, DNA-intercalating and Topo I inhibitors; Kadagathur, M.; Shaikh, A. S.; Panda, B.; George, J.; Phanindranath, R.; Sigalapalli, D. K.; Godugu, C.; Nagesh, N.; Shankaraiah, N.; Tangellamudi, N. D. Bioorg. Chem. 2022, 122, 105706
  12. One-pot, microwave-assisted copper(I)-catalysed dithiocarbamation: facile introduction of dithiocarbamate on imidazopyridines; Laxmikeshav, K.; Sakla A. P.; Shankaraiah, N. Green. Chem., 2022, 24, 1259–1269
  13. Role of Histone demethylases and histone methyltransferases in triple-negative breast cancer: epigenetic mnemonics; Mandumpala, J. J.; Baby, S.; Tom, A. A.; Godugu, C.; Shankaraiah, N. Life Sciences 2022, 292, 120321
  14. Ru(II)-Catalyzed Regioselective C−N Bond Formation on Benzothiazoles Employing Acyl Azide as an Amidating Agent; John, S. E.; Bora, D.; Dhimam, V.; Tokala, R.; Gananadhamu, S.; Shankaraiah, N. ACS Omega 2022, 7, 1299−1310
  15. Exploration of benzimidazoles as potential microtubule modulators: An insight in the synthetic and therapeutic evolution; Laxmikeshav, K.; Ambati, H.; Shankaraiah, N. J. Mol. Str. 2022, 1253, 132251
  16. Expedition of sulfur-containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: A decade update; Laxmikeshav, K.; Kumari, P.; Shankaraiah, N. Med. Res. Rev., 2022, 42, 513-575
  17. Ankaj Kumar, Valamla Bhavana, Thakor P, Padakanti Sandeep Chary#, Naveen Rajana, Neelesh Kumar Mehra. Development and Evaluation of Nanocrystals Loaded Hydrogel for Topical Application . J Drug Delivery science Technology. 2022 in press (Impact factor 3.98)
  18. Deepa Nakmode, Valamla Bhavana, Pradip Thakor, Jitender Madan, Pankaj Kumar Singh, Shashi Bala Singh, Jessica M. Rosenholm, Kuldeep K. Bansal, Neelesh Kumar Mehra. Biopharmaceutical Aspects of Lipid Excipients in Lipid based Formulations. Pharmaceutics. 2022 s 2022, 14, 831 (1-28) (Impact factor 6.3)
  19. Sharma R, Kuche K, Thakor P, Bhavana V, Srivastava S, Mehra NK, Jain S. Chondroitin Sulfate: Emerging biomaterial for biopharmaceutical purpose and tissue engineering. Carbohydrate Polymer. 2022; 286, 119305 (Impact factor 9.38).
  20. Valamla B, Thakor P, Phuse R, Dalvi M, Kharat P, Kumar A, Panwar D, Singh SB, Giorgia P, Mehra NK. Engineering drug delivery systems to overcome the vaginal mucosal barrier: Current understanding and research agenda of mucoadhesive formulations of vaginal delivery. Journal of Drug Delivery Sci Technol. 2022; 70, April 2022, 103162 (Impact factor: 3.98).
  21. Ayusha Dandekar, Natasha Ajokwar, Chanti Katta, Dharmendra Khatri, Vaskuri GS Sainaga Jyothi, Rupinder Kaur sodhi, Neelesh Kumar Mehra, Shashi Bala Singh, Jitender Madan. Inhalable polymeric micro and nano-immunoadjuvants for developing therapeutic vaccines in the treatment of non-small cell lung cancer. Curr Pharm Design. 2021; 17: 1-15 (Impact factor 3.11).
  22. Khatri, D. K.; Preeti, K.; Tonape, S.; Bhattacharjee, S.; Patel, M.; Shah, S.; Singh, P. K.; Srivastav, S.; Gugulothu, D.; Vora, L.; Singh, S. B. Nanotechnological Advances for Nose to Brain Delivery of Therapeutics to Improve the Parkinson Therapy. Curr. Neuropharmacol. 2022, 20. https://doi.org/10.2174/1570159x20666220507022701.
  23. Jyothi, V. G. S. S.; Pawar, J.; Fernandes, V.; Kumar, R.; Singh, C.; Singh, S. B.; Madan, J.; Khatri, D. K. Film Forming Topical Dermal Spray of Meloxicam Attenuated Pain and Inflammation in Carrageenan-Induced Paw Oedema in Sprague Dawley Rats. J. Drug Deliv. Sci. Technol. 2022, 103195. https://doi.org/10.1016/j.jddst.2022.103195.
  24. Singh, S. C.; Choudhary, M.; Mourya, A.; Khatri, D. K.; Singh, P. K.; Madan, J.; Singh, H. Acute and Subacute Toxicity Assessment of Andrographolide-2-Hydroxypropyl-$\upbeta$-Cyclodextrin Complex via Oral and Inhalation Route of Administration in Sprague-Dawley Rats. Sci. World J. 2022, 2022, 1–9. https://doi.org/10.1155/2022/6224107.
  25. Atmakuri, S.; Nene, S.; Khatri, D.; Singh, S. B.; Sinha, V. R.; Srivastava, S. Forging Ahead the Repositioning of Multitargeted Drug Ivermectin. Curr. Drug Deliv. 2022, 19. https://doi.org/10.2174/1567201819666220516163242.
  26. Prajapati, B.; Maji, I.; Kumar, R.; Tomar, D.; Khatri, D. K.; Madan, J.; Singh, P. K. Strategy to Counteract the Pyrazinamide Induced Hepatotoxicity by Developing Naringin Based Co-Amorphous System with Supplementary Benefits. J. Drug Deliv. Sci. Technol. 2022, 69, 103181. https://doi.org/10.1016/j.jddst.2022.103181.
  27. Morya, A.; Chaudhary, M.; Neupane, N. P.; Verma, A.; Sodhi, R. K.; Khatri, D. K.; Madan, J. Iodinated Curcumin as a Novel Anti-Bacterial Agent to Combat Methicillin-Resistant Staphylococcus Aureus in Bovine Mastitis: In Silico Analysis, Synthesis and in Vitro Evaluation. Lett. Drug Des. & Discov. 2022, 19. https://doi.org/10.2174/1570180819666220510125842.
  28. KHATRI, D. K. Polymer Nanotherapeutics: A Versatile Platform for Effective Rheumatoid Arthritis Therapy. J. Control. Release 2022. https://doi.org/10.1016/j.jconrel.2022.05.054.
  29. Jyothi, V. G. S. S.; Ghouse, S. M.; Khatri, D. K.; Nanduri, S.; Singh, S. B.; Madan, J. Lipid Nanoparticles in Topical Dermal Drug Delivery: Does Chemistry of Lipid Persuade Skin Penetration? J. Drug Deliv. Sci. Technol. 2022, 69, 103176. https://doi.org/10.1016/j.jddst.2022.103176.
  30. Sherkhane, B.; Kalvala, A. K.; Arruri, V. K.; kumar Khatri, D.; Singh, S. B. Renoprotective Potential of Myo-Inositol on Diabetic Kidney Disease: Focus on The~role of the {PINK}1/Parkin Pathway and Mitophagy Receptors. J. Biochem. Mol. Toxicol. 2022. https://doi.org/10.1002/jbt.23032.
  31. Gundu, C.; Arruri, V. K.; Sherkhane, B.; Khatri, D. K.; Singh, S. B. Indole-3-Propionic Acid Attenuates High Glucose Induced {ER} Stress Response and Augments Mitochondrial Function by Modulating PERK-IRE1-ATF4-CHOP signalling in experimental diabetic neuropathy. Arch. Physiol. Biochem. 2022, 1–14. https://doi.org/10.1080/13813455.2021.2024577.
  32. Gundu, C.; Arruri, V. K.; Sherkhane, B.; Khatri, D. K.; Singh, S. B. Indole-3-Propionic Acid Attenuates High Glucose Induced ER Stress Response and Augments Mitochondrial Function by Modulating PERK-IRE1-ATF4-CHOP Signalling in Experimental Diabetic Neuropathy. Arch. Physiol. Biochem. 2022, 1–14. https://doi.org/10.1080/13813455.2021.2024577.
  33. Gundu, C.; Arruri, V. K.; Sherkhane, B.; Khatri, D. K.; Singh, S. B. GSK2606414 attenuates PERK/p-eIF2α/ATF4/CHOP axis and augments mitochondrial function to mitigate high glucose induced neurotoxicity in N2A cells. Curr. Res. Pharmacol. Drug Discov. 2022, 100087. https://doi.org/10.1016/j.crphar.2022.100087.
  34. U Brahma, A Suresh, S Murthy, V Bhandari*, P Sharma*. Antibiotics resistance and molecular profiling of the clinical isolates of Staphylococcus aureus causing bovine mastitis from India. Microorganisms, 2022; 10 (4), 833. (Shared corresponding author).
  35. R Kumar, T Amruthanjali, S Singothu, SB Singh, V Bhandari. Uncoupling proteins as a therapeutic target for the development of new era drugs against neurodegenerative disorder. Biomedicine & Pharmacotherapy, 2022: 147, 112656.
  36. Roy, L.; Buragohain, P.; Borse, V. Strategies for Sensitivity Enhancement of Point-of-Care Devices. Biosens. Bioelectron. X 2022, 10, 100098.
  37. Kanchupalli, V.* S. Kumar, S. Nunewar, T. Sabbi, “Synthesis of Indenone Derivatives by Rh(III)-Catalyzed C-H Functionalization of Sulfoxonium Ylides with 1,3-Diynes” Org. Lett. 2022, 24, 3395–3400.
  38. Kanchupalli, V.* S. Nunewar, S. Kumar, H. Pendam P., Pradeep G., “Solvent Controlled Rh(III)-Catalyzed Switchable [4+2] Annulation of 2-ArylIndoles with Iodonium Ylides” Chem. Commun., 2022,58, 6140-6143.
  39. Kanchupalli, V.; Kalepu, J.; Joseph, D.; Arshad, M.; Thorbole, L.; Katukojvala, S. “Rhodium-Catalyzed Enal-Transfer with N-Methoxypyridazinium Salts” Org. Lett. 2022, 24, 3850–3854.
  40. Kanchupalli, V.* S. Kumar, S. Nunewar, “Rh (III)‐Catalyzed Cross‐Coupling/Annulation of Two Carbene Precursors: Construction of Dihydrobenzo [c] chromen‐6‐one Scaffolds and Application in the Total Synthesis of Cannabinol” Asian. J. Org. Chem. 2022, 11, e202100689 (Selected for Hot topic)
  41. Pankaj Goyal, Vartika Mishra, Isha Dhamija, Neeraj Kumar, Sandeep Kumar*, “Immobilization of Catalase on Functionalized Magnetic Nanoparticles: A Statistical Approach”, (2022), 3 Biotech(IF-2.4) doi:10.1007/s13205-022-03173-8
  42. Sabnis Chetan, Joga Ramesh, Simran, Sandeep Kumar, Neeraj Kumar, “The potential of novel self-assembled functionalized carbon nanotubes for selective tumor targeting”, (2022) Pharmaceutical Patent Analyst. (Accepted)
  43. Aslam Saifi, Mohd, Rishabh Hirawat, and Chandraiah Godugu. "Lactoferrin-Decorated Cerium Oxide Nanoparticles Prevent Renal Injury and Fibrosis." Biological Trace Element Research (2022): 1-9.
  44. Anchi, Pratibha, Biswajit Panda, Ravindra Bapu Mahajan, and Chandraiah Godugu. "Co-treatment of Nimbolide augmented the anti-arthritic effects of methotrexate while protecting against organ toxicities." Life Sciences 295 (2022): 120372.
  45. Saifi, Mohd Aslam, and Chandraiah Godugu. "Copper chelation therapy inhibits renal fibrosis by modulating copper transport proteins." BioFactors (2022).
  46. Saifi, Mohd Aslam, Arbaz Sujat Shaikh, Venkata Rao Kaki, and Chandraiah Godugu. "Disulfiram prevents collagen crosslinking and inhibits renal fibrosis by inhibiting lysyl oxidase enzymes." Journal of Cellular Physiology (2022).
  47. Allawadhi, Prince, Amit Khurana, Nilofer Sayed, Chandraiah Godugu, and Divya Vohora. "Ameliorative effect of cerium oxide nanoparticles against Freund’s complete adjuvant-induced arthritis." Nanomedicine 17, no. 6 (2022): 383-404.
  48. Dhurjad, P.; Dhavaliker, C.; Gupta, K.; R. Sonti, Exploring Drug Metabolism by the Gut Microbiota: Modes of Metabolism and Experimental Approaches. Drug Metab Dispos. 2022, 50, 224.
  49. Applications of lipid-engineered nanoplatforms in the delivery of various cancer therapeutics to surmount breast cancer; Gupta, U.; Saren, B. N.; Khaparkhuntikar, K.; Madan, J.; Singh, P. K., J. Control. Release.2022, 22, S0168-3659
  50. Nanomedicine as a magic bullet for combating lymphoma; Mahajan, S.; Aalhate, M.; Guru, S. K.; Singh, P. K., J. Control. Release. 2022, 347, 211-236.
  51. The role of polymers and excipients for better gastric retention of captopril in past two decades; Das, U.; Wadhwa, P.; Singh, P. K.; Kalidindi, D. V.; Nagpal, K., Crit. Rev. Ther. Drug Carr. Syst
  52. Strategy to counteract the pyrazinamide induced hepatotoxicity by developing naringin based Co-amorphous system with supplementary benefits; Prajapati, B.; Maji, I.; Kumar, R.; Tomar, D.; Khatri, D. K.; Madan, J.; Singh, P. K., J Drug Deliv Sci Technol. 2022, 69, 103181.
  53. Development of asolectin-based liposomal formulation for controlled and targeted delivery of erlotinib as a model drug for EGFR monotherapy; Pardeshi, S.; Tiwari, A.; Titame, U.; Singh, P. K.; Yadav, P. K.; Chourasia, M. K., J. Liposome Res. 2022, 1-10.
  54. Identification of possible drug target for NMDA receptor and tau protein by insilico method; Parvatikar, P.; Das, K. K.; Singh, P. K.; Singh, S. B., BLDE Univ. J. Health Sci. 2020, 3, 22.
  55. Priyanka N. Makhal, Srinivas Reddy Dannarm, Rajesh Sonti, Arbaz Sujat Shaikh, Venkata Rao Kaki. TBHP-mediated selenocyclization of N-allylbenzamides/ benzthioamides via in situ generation of “PhSeOH” species. ChemistrySelect, 2022, 7, e202200933.
  56. Sandip Patra, Priyanka N. Makhal, Shubham Jaryal, Nilesh More, Venkata Rao Kaki. Anthocyanins: Plant-based flavonoid pigments with diverse biological activities. Int. J. Plant Bas. Pharm. 2022, 2, 118-127.
  57. Dandekar MP, Palepu MS, Satti S, Jaiswal Y, Singh A, Dash S, Gajula S, Sonti R (2022). Multi-strain Probiotic Formulation Reverses Maternal Separation and Chronic-Unpredictable Mild Stress Generated Anxiety- and Depression-Like Phenotypes by Modulating Microbiome-Gut Brain Activity in Rats. ACS Chemical Neuroscience; 13(13): 1948-1965. (IF: 6.53)
  58. Rahman Z, Pasam T, Rishab, Dandekar MP (2022). Binary Classification Model of Machine Learning Detected Altered Gut Integrity in Controlled-Cortical Impact Model of Traumatic Brain Injury. Int J Neurosci, 1-14.
  59. Akunuri, R.; M, T. U.; Kaul, G.; Akhir, A.; Saxena, D.; Wajidali, M.; Veerareddy, V.; Yaddanapudi, V. M.; Chopra, S.; Nanduri, S. Synthesis and Antibacterial Evaluation of Rhodanine and Its Related Heterocyclic Compounds against S. Aureus and A. Baumannii. Chemistry & Biodiversity (Just accepted).
  60. Kumar Sahoo, S.; Maddipatla, S.; Nageswara Rao Gajula, S.; Naiyaz Ahmad, M.; Kaul, G.; Nanduri, S.; Sonti, R.; Dasgupta, A.; Chopra, S.; Madhavi Yaddanapudi, V. Identification of Nitrofuranylchalcone Tethered Benzoxazole-2-Amines as Potent Inhibitors of Drug Resistant Mycobacterium Tuberculosis Demonstrating Bactericidal Efficacy. Bioorganic & Medicinal Chemistry2022, 64, 116777.
  61. Kumar Sahoo, S.; Maddipatla, S.; Nageswara Rao Gajula, S.; Naiyaz Ahmad, M.; Kaul, G.; Nanduri, S.; Sonti, R.; Dasgupta, A.; Chopra, S.; Madhavi Yaddanapudi, V. Identification of Nitrofuranylchalcone Tethered Benzoxazole-2-Amines as Potent Inhibitors of Drug Resistant Mycobacterium Tuberculosis Demonstrating Bactericidal Efficacy. Bioorganic & Medicinal Chemistry2022, 64, 116777.
  62. Srikanth, D.; Joshi, S. V.; Ghouse Shaik, M.; Pawar, G.; Bujji, S.; Kanchupalli, V.; Chopra, S.; Nanduri, S. A Comprehensive Review on Potential Therapeutic Inhibitors of Nosocomial Acinetobacter Baumannii Superbugs. Bioorg. Chem.2022, 124, 105849.
  63. Chinchilli, K. K.; Royyala, V. N.; Thacker, P. S.; Angeli, A.; Danaboina, S.; Singh, P.; Nanduri, S.; Supuran, C. T.; Arifuddin, M. Design, Synthesis, SAR, and Biological Evaluation of Saccharin-Based Hybrids as Carbonic Anhydrase Inhibitors. Archiv der Pharmazie, e2200019.
  64. Tamang, N.; Andrews, C.; Mavileti, S. K.; Nanduri, S.; Golakoti, N. R.; Karanam, B. Anti-Cancer Activity of Heteroaromatic Acetals of Andrographolide and Its Isomers. New J. Chem.2022, 46 (20), 9745–9754.
  65. Pawar, G.; Mahammad Ghouse, S.; Kar, S.; Manohar Chelli, S.; Reddy Dannarm, S.; Gour, J.; Sonti, R.; Nanduri, S. SmI2-Mediated C-Alkylation of Ketones with Alcohols under Microwave Conditions: A Novel Route to Alkylated Ketones. Chem. -Asian J.2022, 17 (8), e202200041.
  66. Pawar, G.; Ghouse, S. M.; Joshi, S. V.; Rana, P.; Kar, S.; Sarma, P. M.; Dannarm, S. R.; Sonti, R.; Nanduri, S. Cu(I)-Catalyzed Microwave-Assisted Multicomponent Reaction Towards Synthesis of Diverse Fluorescent Quinazolino[4,3-b]Quinazolin-8-Ones and Their Photophysical Study. ChemistrySelect2022, 7 (14), e202200500.
  67. Akunuri, R.; Vadakattu, M.; Kaul, G.; Akhir, A.; Saxena, D.; Ahmad, M. N.; Bujji, S.; Joshi, S. V.; Dasgupta, A.; Yaddanapudi, V. M.; Chopra, S.; Nanduri, S. Synthesis and Antibacterial Evaluation of 3,4-Dihydro-1H-Benzo[b]Azepine-2,5-Dione Derivatives. ChemistrySelect2022, 7 (7), e202104478.
  68. Hopfner, S.M.; Lee, B.S.; Kalia, N.P.; Miller, M.J.; Pethe, K.; Moraski, G.C. (2021) Syntheses and Structure Activity Relationships of N-Phenethyl-Quinazolin-4-yl-Amines as Potent Inhibitors of Cytochrome bd Oxidase in Mycobacterium tuberculosis. Appl. Sci. 2021, 11, 9092. doi: 10.3390/app11199092.
  69. Thomas S.S.,; Kalia N.P.,; Pethe K. (2022) Turbidity-Based MIC Assay and Characterization of Spontaneous Drug Resistant Mutants in Mycobacterium ulcerans. Methods Mol Biol. 2387:209-217. doi: 10.1007/978-1-0716-1779-3_20
  70. Kritika Engle, Gautam Kumar: Cancer multidrug-resistance reversal by ABCB1 inhibition: A recent update. Eur. J. Med. Chem. 2022, 239, 114542

    71. In Press