Name: Dr. Arifuddin Mohammed Assistant Professor arif.niperhyd@gov.in 9347506600 040 23074750

ADDRESS, ROOM NO

Department of Medicinal Chemistry
Rooom No 01
NIPER Hyderabad
Hyderabad – 500037, TS, INDIA

QUALIFICATION: (REVERSE CHRONOLOGICAL ORDER)

• B. Sc. (Chemistry, Biology), 1992, First Division, Osmania University, Hyderabad, A. P., India.
• M. Sc. (English Medium), (Organic Chemistry), 1995, First Division, Osmania university, Hyderabad, A. P., India.
• Ph. D. (Organic Chemistry), 2003 Osmania University. HyderabadIndia.

EXPERIENCE

• Total 7 years of teaching experience
• 15 years of extensive research experience in the design, multistep synthesis and characterization of novel compounds for biological evaluation that leads into drug candidates.

COURSES HANDLING(PHD/M.S(PHARM))

• For M.Pharm
  Logic in Organic Synthesis-I (MC-520)
  Structure and Function of Bio-molecules (MC-630)
  For Ph.D
  Stereo-selective and Stereo-specific Synthesis (MC-710)

PHD STUDENTS/MASTERS STUDENTS

• 1 Ph.D. Submitted,
  
• 2 Ph.D. Ongoing
  
• 23 Students Completed
  
• and 7 Ongoing
  

AWARDS / HONOURS

• ASSOCIATE FELLOW OF TELENGANA ACADEMY OF SCIENCES (2016)


• Post Doctoral Research Fellowship, (2003-2004) Departments of Molecular Biology & Chemical Biology, The Scripps Research Institute, CA, USA.


• Post Doctoral Research Fellowship, (2001-2002), Centre de Biophysique Moleculaire, CNRS, Rue Charles Sadron, 45071, Orleans Cedex 02, France.


• Senior Research Fellowship (1999) awarded by Council of Scientific and Industrial Research (CSIR) India.

RESEARCH AREAS/INTEREST

• Synthetic Organic Chemistry, Medicinal Chemistry, Bioorganic Chemistry and Development of New Methodology in Organic synthesis.

SPONSORED PROJECTS

• Project Title: “Design and Development of novel anti-tubercular agents targeting Shikimate Kinase protein"
  Funding agency: DBT, India (Sanction Order for Project,
  BT/PT23619/MED/29/1199/2017)

PUBLICATIONS / BOOK CHAPTERS

• Publications: 34 national and international papers
  Review Articles: two review article
  Presentations: 19 poster presentations at national and international
  seminars

PATENTS

• Patents: Three international patents

INVITED TALKS

• None

ADDITIONAL RESPONSIBILITIES

• None

ANY OTHER INFORMATION

• None

List of Publications of Dr. Mohammed Arifuddin:

1. Improved efficient conversion of aldehyde to nitriles Via their N, N -dimethyl hydrazones. Ahmed Kamal, M.Arifuddin and N. V. Rao Synthetic Communication 1998, 28, 4507. IF:- 1.062
2. Facile transformation of N, N- dimethylhydrazones and tosylhydrazones to ketones with dimethylsulfate and potassium carbonate. Ahmed Kamal, M.Arifuddin and N.V.Rao.
Synthetic Communication 1998, 28 (21) 3927. IF:- 1.062 3. Enatioselective ring opening of epoxide with TMSN3 in the presence of ・ - cyclodextrin: An efficient route to 1, 2-azido alcohols. Ahmed Kamal, M.Arifuddin and Maddamshetty.V.Rao. Tetrahedron Asymmtry, 1999, 10 , 4261. IF:- 2.652
4. An efficient and rapid regeneration of carbonyl compounds from their N, N - dimethylhydrazones by chlorotrimethylsilane/sodium iodide Ahmed Kamal , M. Arifuddin and K. Venkata Ramana Chemistry Letters. 1999, 827. IF:- 1.587
5. An efficient reduction of azides to amines: Synthesis of DNA interactive pyrrolo [2,1-c] [1,4] benzodiazepines. Ahmed Kamal, E. Laxman and M. Arifuddin Tetrahedron Letters. 2000. 41, 7743. IF:- 2.683
6. Facile and rapid regeneration of carbonyl compounds from their N, N -dimethyl hydrazones employing transition metal complexes. Ahmed Kamal, M. Arifuddin and M. V. Rao Synthetic Letters. 2000, 1482. IF:- 2.71
7.A one-pot, efficient and facile synthesis of 4β-arylaminopodophyllotoxins: Synthesis of NPF and GL-331 as DNA-topoisomerase II inhibitors Ahmed Kamal, B. Ashwini Kumar and M. Arifuddin, Tetrahedron Letters. 2003, 44, 8457. IF:- 2.683
8.Synthesis and biological activity of new 4・-amido and 4・-sulphonamido analogoues of podophyllotoxin Ahmed Kamal, B. Ashwini Kumar, M. Arifuddin Bio-Org. Med. Chem. 2003, 11, 5135. IF:- 2.921
9.Design, synthesis, biological evaluation and QSAR studies of novel bisepipodophyllotoxins as cytotoxic agents. Kamal, Ahmed; Laxman, E.; Ramesh Khanna, G. B.; Reddy, P. S. M. M.; Rehana, Tasneem; Arifuddin, M.; Neelima, K.; Kondapi, Anand K.; Dastidar, Sunanda G. Bio-Org. Med. Chem. 2004, 12, 4197-4209 IF:- 2.921
10.An efficient and facile nitration of aromatic compounds with nitric acid/zinc chloride under ultrasonic conditions Ahmed Kamal, B. Ashwini Kumar, M. Arifuddin and Midoux Patrick Ultrasonics Sonochemistry. 2004, 11, 455-457. IF:- 3.567 11.Ultrasonic activated efficient and facile method for the cleavage of epoxides with aromatic amines Ahmed Kamal, S. F. Adil and M. Arifuddin, Ultrasonics Sonochemistry, 2005,12, 429-431. IF:- 3.567
12.Bi(OTf)3-catalyzed Regioselective Ring Opening of Epoxides with Phenols: Facile Synthesis of 1,3-Diaryloxy-2-propanols Ahmed Kamal, Syed Kaleem Ahmed, Mahendra Sandbhor, Mohammed Naseer Ahmed Khan and Mohammed Arifuddin Chemistry Letters, Vol. 34, 2005, No. 8, 1142-1143 IF:- 1.587
13.Synthesis and biological evaluation of new 4β-anilino- and 4β-imido-substituted podophyllotoxin congeners Ahmed Kamal, N. Lakshmi Gayatri, D. Rajasekhar Reddy, P. S. Murali Mohan Reddy, M. Arifuddin, Sunanda G. Dastidar, Anand K. Kondapi and M. Rajkumar Bioorganic & Medicinal Chemistry, 2005, 13, 6218-6225. IF:- 2.921
14.Synthesis and Biological Activity of New 4β-N-Heteroaryl Analogues of Podophyllotoxin Ahmed Kamal, B. Ashwini Kumar, M. Arifuddin , Sunanda. G. Dastidar Letters in Drug Design & Discovery, 2006, 3, 3 , 205-209 IF:- 0.872
15.Mild and Efficient Nitration of Aromatic Compounds Mediated by Transition Metal Complexes Abdulla, Amina S, Arun Kumar Y, Arifuddin M, Rajanna K C Synthetic Communication, 2011, 19, 2946-2951 IF:- 1.062
16.Zinc Chloride Promoted Efficient and Facile BOC Protection of Amines M Arifuddin, N Lakshmikant, N Rajasekar & D B Shinde Indian Journal of Chemistry, Section B, 2012. 51 (B), 1168-1172 IF:- 0.648
17.Transition Metal Ions as Efficient Catalysts for Facile Ortho-Formylation of Phenols under Vilsmeier–Haack Conditions
F. Aneesa, K. C. Rajanna, Y. Arun Kumar, and M. Arifuddin Organic Chemistry International, Volume 2012 (2012), Article ID 289023, 7 pages
18.Transition metal complexes mediated efficient and facile cleavage of oximes and phenylhydrazone to carbonyl compounds Wajid Syed, Tasneem Mohammed, Arifuddin Mohommed, Mohamed N Al-Arifi Asian Journal of Pharmaceutical and Clinical Research (Asian J Pharm Clin Res), 2015, 8 (3), 96-98. IF 0.74 19.Evaluation of analgesic and anti-inflammatory activities of formulation containing camphor, menthol and thymol. Syed Safiullah Ghori, Md Ikram Ahmed, Md. Arifuddin, Md Shoaibuddin Khateeb, International Journal of Pharmacy and Pharmaceutical Sciences, (Int. J. Pharm. Pharm. Sci) 2016, 8 (1), 271-274. (Current impact factor: 1.59).
20.Transition metal ions as catalysts for efficient formylation of hydrocarbons with Vilsmeier - Haack reagents: Kinetics and mechanism K. C. Rajanna., Aneesa Ferdose., K. Rajender Reddy., Md. Arifuddin., M. Moaazzam Ali., Journal of Solution Chemistry, March 2016, Volume 45, Issue 3, pp 371-394 (Impact Factor -1.177)
21. Isolation of phytosterols from the methanolic extract of leaves of Ficus dalhousiae Miq Safiullah S G., Shazia S., Fouzia F., Ummara H., Arifuddin M., Tasneem M. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 7(4) 2016 (Ref.No: RJPBCS/2010-7744) (Impact Factor -0.35)
22.Discovery of 4-sulfamoyl-phenyl-β-lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors: the first example of subnanomolar CA IV inhibitors Srinivas Angapelly, P.V. Sri Ramya, Andrea Angeli, Simona Maria Monti, Martina Buonanno, Mallika Alvala, Cladiu T. Supuran, Mohammed Arifuddin Bioorganic & Medicinal Chemistry, 2017, 25,(2), 15 Pages 539–544 (Impact Factor: 2.923 )
23.Ultrasonic Accelerated Efficient & Mild Chemo-Selective Synthesis Of 2-Aryl-1- Arylmethyl-1H-1,3-Benzimidazoles Promoted By Ammonium Molybdate; Prathapa Reddy Madddiguda, Srinivas Angapalley, Shweta Sawner, & Arifuddin Mohammed.; Heterocyclic Letters, 2017, 7, 1, 65-73. 24.Metal-Free C‒C Bond Cleavage: One-Pot Access to 1,4-Benzoquinone linked N-Formyl Amides/Sulfonamides/ Carbamates using Oxone P.V. Sri Ramya, Srinivas angapelly, Bathini Nagendra Babu, chander singh Digwal, Atulya Nagarsenkar, Gannoju Srinivasulu, B Prasanth, Mohammed Arifuddin, Kumar Kanneboina, Krishnan Rangan and Ahmed Kamal Asian Journal of Organic Chemistry, 2017, 6, 8, 1008–1013 (Impact Factor: 3.275)
25.Development of sulfonamides incorporating phenylacrylamido functionalities as carbonic anhydrase isoforms I, II, IX and XII inhibitors SrinivasAngapelly, P.V. Sri Ramya, AndreaAngelib, Sonia Del Prete,Clemente Capasso, MohammedArifuddin, Claudiu T. Supuran Bioorganic & Medicinal Chemistry, 2017, 25, 20, 5726-5732. (Impact Factor: 2.923 )
26.Novel sulfocoumarin/coumarin/4-sulfamoylphenyl bearing indazole-3-carboxamide hybrids: Synthesis and Selective inhibition of tumor associated carbonic anhydrase isozymes IX and XII, Srinivas Angapelly, P. V. Sri Ramya, Andrea Angeli, Claudiu T Supuran and Mohammed Arifuddin ChemMedChem, 2017, 12, 19,1578–1584 (Impact Factor: 3.225)
27.Discovery of curcumin inspired sulfonamide derivatives as a new class of carbonic anhydrase isoforms I, II, IX and XII inhibitors P.V. Sri Ramya, Srinivas Angapelly, Andrea Angeli, Chander Singh Digwal, Mohammed Arifuddin, Bathini Nagendra Babu, Claudiu T. Supuran and Ahmed Kamal Journal Of Enzyme Inhibition And Medicinal Chemistry, 2017, 32,1,1274-1281. (Impact Factor: 4.293)
28.Ultrasound assisted, VOSO4 catalyzed Synthesis of 4-thiazolidinones: Antimicrobial Evaluation of indazole-4-thiazolidinone derivatives Srinivas Angapellya, P.V. Sri Ramyaa, Routhu Sunitha Ranib, C. Ganesh Kumarb, Ahmed Kamala, Mohammed Arifuddin Tetrahedron Letters, 2017, 58, 4632-4637 (Impact Factor: 2.193)
29.Iodine-mediated one-pot intramolecular decarboxylation domino reaction for accessing functionalized 2-(1,3,4-oxadiazol-2-yl)anilines with carbonic anhydrase inhibitory action, Srinivas Angapelly, P. V. Sri Ramya,a RohiniSodhi, Andrea Angeli, Krishnan Rangan, Narayana Nagesh, Claudiu T. Supuran and Mohammed Arifuddin. Journal of Enzyme Inhibition and Medicinal Chemistry - 2018, 33 (1),615-618, (Impact Factor: 4.293)
30.Werner Transition Metal Complexes (WTMC) Mediated, Mild and Efficient Chemo-selective Acylation of Phenols and Anilines under Solvent free Condition. Sarief, Abdulla, Haque, Sk Manirul, Arifuddin, Mohammed, Syed Mudabbir Feroze, Journal of the Chinese Chemical Society,2018 Manuscript ID jccs.201800013 (accepted with revision). (Impact factor: 0.935)
31.An efficient and facile Green synthesis of Bisindole Methanes as potential Mtb FtsZ inhibitors. Pratima Khadkikar, Sridhar Goud, Arifuddin Mohammed, Ananthathatmula Ragamanvitha, Arshad Rizvi, Sharmista Banerjee, Mukesh Doble, Mallika Alvala. Chemical Biology & Drug Design, Manuscript ID CBDD-RA-12-17-4017 (Accepted with revision) (Impact factor:2.396)
32.Anti-nociceptive mechanisms of flavonoids – rich methanolic leaf extract from Terminalia coriacea (Roxb.) Wight & Arn. Leaves Mohammed Safwan Ali Khan, Nishat Ahmed, Misbah, Mohammed Arifuddin, Zainul Amiruddin Zakaria, Mohammad M.Al-Sanea, Syeda Umme Kulsoom Khundmiri, Inshah Ahmed, Saleha Ahmed, Pooi Ling Mok. Food and Chemical Toxicology, 2018,115, 523-531 (Impact Factor: 3.778)
33.Synthesis and Biological Evaluation of 4-sulfamoylphenyl/sulfocoumarin carboxamides as selective inhibitors of carbonic anhydrase isoforms hCA II, hCA IX and hCA XII. Srinivas Angapelly, Arbaj Jabbar Khan, P. V. Sri Ramya, Andrea Angeli, Claudiu T. Supuran, Mohammed Arifuddin, ChemMedChem, 2018, Accepted (Impact Factor: 3.225)
34.Indole alkaloids and anti-nociceptive mechanisms of Tabernaemontana divaricata (L.) R. Br. flower methanolic extract; Mohammed Safwan Ali Khan, Misbah, Nishat Ahmed, Mohammed Arifuddin, Abdullah Rehman, Mok Pooi Lingb; Food and Chemical Toxicology, 2018,(Accepted) (Impact Factor: 3.778) (doi.org/10.1016/j.fct.2018.06.007)

Review Article:

1.Diverse Pharmaceutical Efficacy of 2-chloro-3-formylquinoline Derivatives- A Review Arifuddin Mohammed., Srinivas Angapally. Current Trends in Pharmaceutical Sciences., 2014, 2, 2-3, 64-75.

2.Diverse Pharmacological Aspects Of 2-Amino-4-Phenylthiazole Derivatives-A Review Mohammed Arifuddin*, Neeraj Kumar Chauhan, Laxmi keshav Kritika, Pramod Kumar Dubey Heterocyclic Letters,Vol. 7| No.4| |Aug-Oct|2017(ISSN : (print) 2231–3087 / (online) 2230-9632 CODEN: HLEEAI) http://heteroletters.org

Patents:

1. A Process for the synthesis of new podophyllotoxin dimers as potential DNA -Topoisomerase II inhibitors. Ahmed. Kamal, E. Laxman, M. Arifuddin, G. B. R. Khanna, J. S. Yadav, K. V. Raghavan Indian Patent Appl. No. 381/DEC/2001 dated. 29.03.01 US Patent :- 6441198.
2. Podophyllotoxin derivatives as antitumour agents Ahmed Kamal, M. Arifuddin, B. Ashwini Kumar. Applied for Indian Patent. Appl.No:- 139/DEL/2003.
3. Prepn. of 4・-amino and 4・-amido derivatives of podophyllotoxin and 4'-Odemethylepipodophyllotoxin as antitumor agents.
Kamal Ahmed, Arifuddin Mohammed, Kumar Banala Ashwani, Dastidar Sunanda Ghose. PCT Int. Appl. (2004), WO 2004073375

Presentations:

1.New method for the conversion of thiocarbonyl compounds to carbonyl compounds. Ahmed Kamal, B. S. P. Reddy, B. S. N. Reddy. E. Laxman and M. Arifuddin Presented in Indo-German Symposium "Organic Synthesis-Growing interface with adjacent sciences” Sept 27-28. 1997. at IICT. Hyderabad.
2.Stereo selective enzymatic amidation of azido functionality. Synthesis of 4・・- amidopodophyllotoxin congeners by bakers yeast Ahmed Kamal, M. V. Rao, M. Arifuddin and N. L. Gayatri.
Presented in "Chira Tech 97" November 11-13, 1997, at Philadelphia, Pennsylvania, 19106, USA.
3.Enatioselective ring opening of epoxide with TMSN3 in the presence of ・ - cyclodextrin. An efficient route to1, 2-azido alcohols Ahmed Kamal, M. Arifuddin and Maddamshetty.V. Rao. Presented in National Symposium on Green Chemistry. New Delhi. India January 11-13 1999.
4.Synthesis and anticancer activity of new 4・-amino substituted congeners of podophyllotoxin. Ahmed Kamal, G. Ramesh, N. L. Gayatri and M. Arifuddin Presented in "Second National Symposium in Chemistry "IICT Hyderabad, India January 27-29, 2000.
5.Design and synthesis of novel podophylotoxin dimers as potential DNA-topoisomerase II inhibitors. Ahmed Kamal E. Laxman and M. Arifuddin
Presented in Vth Internation Symposium on Bio-organic Chemistry (ISBOC 2000) (IUPAC) January 31- Feb-4, 2000. Pune. India 6.Synthesis and anticancer activity of new 4- ・- amino substituted congeners of podophyllotoxin. Ahmed Kamal, G. Ramesh, N. L. Gayatri and M. Arifuddin Presented in Second National Symposium in Chemistry Jan 27-29, 2000, IICT, Hyderabad, India
7.Synthesis of new analogues of podophyllotoxin as topoisomerase II inhibitors. Ahmed Kamal, B. Ashwini Kumar, and M. Arifuddin Ramanbhai Foundation 1st Internation Symposium Jan 23-24, 2003, Ahemadabad, India.
8.Design, Synthesis, Characterization and Biological Activity of Schiff’s Bases Derived from 2-Chloro-3-Formylquinoline and its Metal Complexes Yamuna Penuka, Shabaz Eqbal, C. Rohit, Talla Venu, Md. Arifuddin,* Kolupula Srinivas, MEDCHEM congress-25-26-February 2011. IICT/NIPER-Hyderabad.
9.Molecular mechanism involved in the anti-nociceptive activity of Terminalia Coriacea (Roxb.) wright & arn. Leaf methanolic extract, isolation and characterization of three flavonol glycosides Syed azizullah Ghori., Mohammed Safwan Ali Khan., Nishat Ahmed., Mohammed Arifuddin., Zainul Amiruddin Zakaria International Anatomical and Biomediccal Scientific Conferences 2015 ( IABS-2015), 18th -20th August 2015, Faculty of Medicine and health Sciences, Univeriti Putra Malaysia, Malaysia.
10.In-vivo mechanistic evidences of anti-nociceptive effect, isolation and characterization of indole alkaloids from Tabernaemontana divericata {L.} R. Br. Flower methanolic extract Mohammed Saafwan Ali Khan., Abdul Manan mat Jais., Misbah M., Mohammed Arifuddin., Norhafizah Mohtarrudin International Anatomical and Biomediccal Scientific Conferences 2015 ( IABS-2015), 18th -20th August 2015, Faculty of Medicine and health Sciences, Univeriti Putra Malaysia, Malaysia.
11.Synthesis and molecular docking studies of 4-91,3-Thiazol-2-yl)morpholine-benzamidazole conjugates as dual mTOR/P13K・ inhibitors. Shams Aaghaz, Chander Singh Digwal, Upasana yadav, M. Arifuddin, Ahmed Kamal. International Conference on “ Biochemistry, Nutrition and Pharmacy in human welfare: recent trends and future challenges”.2-5 September-2015 Department of Biochemistry, Osmania University, Hyderabad. (Got best poster Award)
12.Mild and selective synthesis of 2-aryl-1-arylmethyl-1H-benzimidazoles Shweta Sawner, Prathapa R. M., Srinivas A., Arifuddin M. International Conference on “ Biochemistry, Nutrition and Pharmacy in human welfare: recent trends and future challenges”.2-5 September-2015 Department of Biochemistry, Osmania University, Hyderabad.
13.Ammonium molybdate mediated efficient and facile synthesis of Dihydropyrimidones Sonal B., Pavitra S. T., Arifuddin M. International Conference on “ Biochemistry, Nutrition and Pharmacy in human welfare: recent trends and future challenges”.2-5 September-2015 Department of Biochemistry, Osmania University, Hyderabad.
14.Design of Novel Anti-staphyloccal agents acting against bacterial cell division protein (Ftsz) using computer aided drug design. Mugilarasi P., Mallika M., M. Arifuddin International Conference on “ Biochemistry, Nutrition and Pharmacy in human welfare: recent trends and future challenges”.2-5 September-2015 Department of Biochemistry, Osmania University, Hyderabad. (Got best poster Award)
15.Antimicrobial activity of Ficus dalhousiae miq. Leaf extract andstigmasterol from it. Syed safiullah ghori, Fouzia Fatima, Mohammed Arifuddin, Shazia Siddiqua & Umme Ummara Conference on Drug Discovery & Development (Global Scenario-Indian perspective), 20-21 November 2015. NIPER-Hyderabad, India.
16.Design, synthesis and biological evaluation of 8-hydroxyquinoline-4-Thiazolidnone derivatives Srinivas Angapally, Jagruthi. P., Mohammed Arifuddin Conference on Drug Discovery & Development (Global Scenario-Indian perspective), 20-21 November 2015. NIPER-Hyderabad, India.
17.Development of small molecules targeting bacterial cell division protein (Ftsz) as anti- staphyloccal agents usingcomputational approach. Mugilarasi P., Mallika M., M. Arifuddin., Alvala R. International Conference and Workshop on Structure based Designing & Application to infectious Diseases. 1st-5th Feburary 2016, School of Life Sciences, University of Hyderabad, Hyderabad. India. 18.Shweta Sawner, Srinivas A. & Arifuddin M.; Ultrasound Accelerated Synthesis of Novel Benzimidazole Derivatives as Potential Anticancer Agents, National Symposium on Recent Trends in Green Chemstry and Technology (RTGC), 27th-28th February, 2017, Department of Chemistry, Anwar-ul-uloom College (autonomous), Hyderabad-1.T.S.
19.Novel Sulfocoumarin/Coumarin/4-Sulfamoylphenyl Bearing Indazole-3-Carboxamide Hybrids: Synthesis and Selective Inhibition Of Tumor Associated Carbonic Anhydrase Isozymes IX And XII, Srinivas Angapelly, P.V. Sri Ramya, Andrea Angeli, Claudiu T. Supuran, Mohammed Arifuddina*SPER 7th Annual International Conference & Exhibition [SPER 2018], B.S. Abdur Rahman Crescent Institute of Science and Technology, Chennai [Tamil Nadu], 23rd-24th February,2018. (Poster number- PCH 03)