Faculty & Staff
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Qualification:
- Ph.D.(Chemistry):
Indian Institute of Chemical Technology (IICT), Hyderabad, India (February 2001- March 2006)
- M.Sc (Physical Organic Chemistry): Osmania University, Hyderabad, India; (1998-2000)
Experience:
- Assistant Professor at NIPER-Hyderabad since March 2009.
- Post Doctoral Research: European Institute of
Chemistry & Biology (IECB), University of Bodeaux-1, Pessac, France (2006 -
2009)
- Research Associate:
Institute of Chemistry, Academia Sinica, Taiwan (2006 - 2006)
Research Area of Interest:
- Molecular Modeling / Computer Aided Drug Design
- Peptidomimetics / Novel Drug Delivery Systems
- Computational Photochemistry / Reaction Mechanisms
Awards / Fellowships:
- OPPI Young Scientist Award 2011 –
by Organization of Pharmaceutical Producers of India
- Young Foreign Research Fellow 2006- French Ministry of Research, France
- CSIR-Senior Research Fellowship 2003, India
- CSIR-Junior Research Fellowship 2001, India
Publications:
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Anticancer siRNA delivery by new anticancer molecule: A novel combination strategy
for cancer cell killing
Prathap Reddy Muktapuram, Rishi Kumar gara, Komal Sharma, Chilappa Rohit,
Kolupula Srinivas, Durga Prasad Mishra, Surendar Reddy Bathula*
European Journal of Medicinal Chemistry, 2012 (Accepted)
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Unusual Regioselective Electrophilic Substitutions in Quinoline Foldamers: Conceptual DFT and FMO Analysis Reveal the Crucial Role of Folding and Substituents
Madishetti Shravani, Kolupula Srinivas*, K. Bhanuprakash, Ivan Huc
ChemPhysChem 2012 (Accepted)
- Synthesis and Evaluation of Novel 2-Pyridone Derivatives as Inhibitors of Phosphodiestarase3 (PDE3): A Target for Heart Failure and Platelet Aggregation
Mettu Ravinder, Budde Mahendar, Saidulu Mattapally, Kommi Venkata Hamsini, Thatikonda Narendar Reddy, Chilappa Rohit, Kolupula Srinivas,* Sanjay Kumar Banerjee,* Vaidya Jayathirtha Rao*
Bioorg. Med. Chem. Lett., 2012 (In Press)
- The ESI-CAD fragmentations of protonated 2, 4, 6-tris(benzylamino)- and tris (benzyloxy)-1,3,5-triazines, involve benzyl-benzyl interactions: A DFT study
M. Ramesh, B. Raju, M. George, Kolupula Srinivas, V. Jayathirtha Rao, K.
Bhanuprakash, R. Srinivas*
J. Mass Spectrom. 2012 (In Press)
- Conformational Analysis of 2-Anthrylethylelne derivatives: Photochemical and Computational Investigation
U. Srinivas, Kolupula Srinivas*, P. Arun Kumar, K. Bhanuprakash* and V.
Jayathirtha Rao*
J. Struct. Chem. 2012 (In Press)
- Synthesis and in vitro Anti Cancer Activity of Novel Rhodanine Derivatives
Boddu Ananda Rao, V. G. M. Naidu, Ravindra Singh Rajpooth, Kolupula Srinivas*, Sistla Ramakrishna*, Vaidya Jayathirtha Rao*
Int. J. Pharma and Bio Sciences 2011, 2, 191
- Remote substituent effects and regioselective enhancement of electrophilic substitutions in helical aromatic oligoamides
Kolupula Srinivas, Brice Kauffmann, Christel Dolain, Jean-Michel léger, Léon Ghosez, Ivan Huc
J. Am. Chem. Soc., 2008, 130, 13210-13211
- Converting Sequences into Aromatic Amino Acid Monomers into Functional Three-Dimensional Structures: Second-Generation of Helical Capsules
Chunyan Bao, Brice Kauffmann, Quan Gan, Kolupula Srinivas, Hua Jiang, Ivan Huc; Angew. Chem. Intl. Ed. 2008, 47, 4153-4156
Research work of this article is highlighted in Nature Chemistry 2008
(http://www.nature.com/nchem/reshigh/2008/0508/full/nchem.9.html)
- Synthesis and antibacterial activity of 2,4,6-tri substituted s-triazines.
K. Srinivas, U. Srinivas, V. Jayathirtha Rao, K. Bhanuprakash, Hara Kishore, U. S. N. Murthy;
Bioorg. Med. Chem. Lett., 2005, 15, 1121-23
- Synthesis and antibacterial activity of various substituted s-triazines
K. Srinivas, U. Srinivas, V. Jayathirtha Rao, K. Bhanuprakash, Hara Kishore, U. S. N. Murthy;
Eur. J. Med. Chem., 2006, 41, 1240-1246
- Tautomerism of bis (2, 4- benzyloxy)-6-(5H)-1,3,5-triazine: A combined crystallographic and quantum-chemical investigation
K. Srinivas, Sanyasi Sitha, B. Sridhar, V. Jayathirtha Rao, K. Bhanuprakash,
K. Ravikumar;
Structural Chemistry 2006, 17, 561-568
- NLO activity in nonconjugated 3D triazine derivatives: Noncentrosymmetric crystal through conformational flexibility
K. Srinivas, Sanyasi Sitha, V. Jayathirtha Rao, K. Bhanuprakash, K. Ravikumar
J. Mater. Chem., 2006, 16, 496-504
- First hyperpolarizability of some nonconjugated donor–acceptor 3D molecules: Noncentrosymmetric crystal through conformational flexibility
K. Srinivas, Sanyasi Sitha, V. Jayathirtha Rao, K. Bhanuprakash, K. Ravikumar, S. Philip Anthony, T. P. Radhakrishnan
J. Mater. Chem., 2005, 15, 965-973
- Second order NLO response in mono- and di-Substituted triazine derivatives: A combined experimental and theoretical analysis
K. Srinivas, Sanyasi Sitha, V. Jayathirtha Rao, K. Bhanuprakash
Optical Materials 2006, 28, 1006-1012
- Crystal Structure of 2,4-bis [(Z)-2-(4-methoxyphenyl) ethenyl]-6- methyl-1, 3, 5-triazine;
B. Sridhar, K. Ravikumar, K. Srinivas, V. Jayathirtha Rao, K. Bhanuprakash;
Analytical Sciences 2006, 22, x105-106
- Linear allenic linkage for nonlinear optics: A computational study of the role of mutually orthogonal -orbitals in controlling the charge transfer, hyperpolarizability and absorption properties in some donor-acceptor substituted allenes.
Sanyasi Sitha, K. Srinivas, P. Raghunath, K. Bhanuprakash, V. Jayathirtha Rao;
J. Mol. Struct.: THEOCHEM 2005, 728, 57-65
- Ionic photo-dissociation of Arylallyl acetates; G. Venugopal Rao, M. Janakiram Reddy, K. Srinivas, Maruthi Janakiram Reddy, K. Mani Bushan and V. Jayathirtha Rao;
Photochemistry & Photobiology 2002, 76, 29-34
- Photochemical E (trans)-Z (cis) isomerization in 9-Anthracene acrylicesters
M. Janakiram Reddy, U. Srinivas, K. Srinivas V. Venkat Reddy and V. Jayathirtha Rao;
Bull. Chem. Soc. Japan 2002, 75, 2487-2495
- Unusual Regioselective Electrophilic Substitutions in Quinoline Foldamers: Conceptual DFT and FMO Analysis Reveal the Crucial Role of Folding and Substituents
Madishetti Shravani, Kolupula Srinivas, Kotamarthi Bhanuprakash, Ivan Huc,
J. Phys. Chem. B 2011 (Communicated)
Book Chapter:
Oxa-Di-π-Methane Rearrangement of β,γ-Unsaturated Ketones
V.Jayathirtha Rao and Kolupula Srinivas
Book Chapter in CRC Handbook of Photochemistry and Photobiology 3rd Edition, CRC Press, New York (Accepted) 2011
Full Papers Published in Conferences
Design and in-silico studies of (4-(1-(4-(sulfonamide/methylsulfonyl) phenyl) -3- (trifluoromethyl/methyl) -1H - pyrazol-5-yl) dine urea and amide derivatives as novel potent dual active agents: Selective COX-2 and soluble epoxide hydrolase (sEH) inhibitors
Krishnam Raju Atcha,* Kolupula Srinivas, Sahishna .M. Phaniraj, Vijaykumar D Nimbarte, Hadianawala Murtuza
International Conference on Biologically Active Molecules (ICBAM-2012) by Gandhigram Rural Institute, Tamilnadu, India; 8th-10th March 2012.
Symposiums / Conferences Conducted:
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Convener, Workshop on Bioinformatics@BioAsia 2012, Organized by NIPER-Hyderabad and BioAsia 2012 @ NIPER-Hyderabad, February 9, 2012
- Convener, 2nd PharmSci@India 2011 International Symposium, organized by NIPER-Hyderabad and National University of Singapore (AAPS-NUS Student Chapter) @ NIPER-Hyderabad 3rd – 4th September 2011
- Convener, Workshop on Computer Aided Drug Design and Discovery (CAD3-2011) @ NIPER-Hyderabad, April 15-17, 2011
- Active Member, International Conference: MEDCHEM Congress – 2011
Conducted by NIPER-Hyderabad, IICT & RSC, London @ NIPER-Hyderabad & IICT, Hyderabad; February 25-26, 2011
- Active Member, Workshop on Drug Discovery: Drug Design, Development, Delivery and Preclinical Studies (D4PS-2010) (Module 1-3), October-November 2010 @ NIPER-Hyderabad & IICT, Hyderabad
- Convener, Summer Workshop on Computer Aided Drug Design and Discovery (CAD3-2010) @ NIPER-Hyderabad, 30th April – 2nd May 2010
- Active Member, 12th CRSI Symposium in Chemistry @ IICT, 5-7th February 2010
7. Active Member, 4th CRSI-RSC Symposium in Chemistry @ NIPER-Hyderabad, 4th February 2010
Poster Presentations:.
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In silico design of Foldamers and Investigation of their Potential as Molecular Drug Delivery Systems
Kolupula Srinivas, * Shalini Nekkanti
International Symposium on “Airways Diseases: Etiology to Clinic” organized by Daiichi Sankyo India Pharma Pvt Ltd and Ranbaxy Laboratories Ltd @ Gurgaon, Delhi, India; 24th-25th February 2012
- Conjugation Induced Ionic Photo-dissociation in Arylallylacetates: Computational Study and Experimental Validation
Boddu Ananda Rao, Kolupula Srinivas*, Maruthi Janakiram Reddy, Uppalanchi Srinivas, Vaidya Jayathirtha Rao*, K. Bhanuprakash*
International Conference on “TAP SUN: The Sustainable Future” Jointly organized by IGNA & IICT, Hyderabad @ IICT-Hyderabad, India
November 24-25, 2011
- Folding Induced Regioselectivity and Rate Acceleration in Helically folded Oligomers: Molecular Modeling study
Madishetti Shravani, Kotamarthi Bhanuprakash, Kolupula Srinivas*
MEDCHEM Congress – 2011 by IICT, NIPER-Hyderabad & RSC, London; February 25-26, 2011(1st Best Poster Award)
- Role of Steric and Electronic effects in Folding Propensities of Quinoline Oligoamides
Kolupula Srinivas, Priya Pandey, Brice Kuffman, Leon Ghosez, Ivan Huc
MEDCHEM Congress – 2011 by IICT, NIPER-Hyderabad & RSC, London; February 25-26, 2011
- Design, Synthesis, Characterization and Biological Activity of Schiff’s Bases Derived from 2-Chloro-3-Formylquinoline and its metal Complexes
Yamuna Penuka, Shabaz Eqbal, C. Rohit, Talla Venu, Md. Arifuddin, Kolupula Srinivas*
MEDCHEM Congress – 2011 by IICT, NIPER-Hyderabad & RSC, London; February 25-26, 2011
- Synthesis, in Vitro Anti Cancer Activity and Molecular Docking Studies of Novel Rhodanine Derivatives
Boddu Ananda rao, Ravindra Singh Rajpoot, V.G.M.Naidu, Kolupula Srinivas*, Sistla Ramakrishna*, V. Jayathirtha Rao
MEDCHEM Congress – 2011 by IICT, NIPER-Hyderabad & RSC, London; February 25-26, 2011.
- Novel Rhodanine derivatives as PPAR-g Agonists: Design, Synthesis and Antidiabetic Activity Evaluation
V. Ramesh, B. Ananda Rao, Pankaj Sharma, Archana Yadav, Kolupula Srinivas*, Swetha Ld, Kulkarni Prasad, Sistla Ramakrishna*, V. Jayathirtha Rao*
MEDCHEM Congress – 2011 by IICT, NIPER-Hyderabad & RSC, London; February 25-26, 2011
- Self-assembled functionalized oligoamide foldamer as bioinspired protein like nano-materials
Xavier de Hatten, Kolupula Srinivas, Ivan Huc
Nano South-West European Conference, November 3-5, 2008
- Design and Synthesis of near UV-absorbing and thermally stable imidazole
chromophores for NLO applications
Ch. Prabhakar, Avinash L. Puyad, Kolupula Srinivas, V. Jayathirtha Rao, K. Bhanuprakash
Heterocyclic Chemistry Symposium, Saifabad, Hyderabad (India) 2006
(Best Poster Award)
- Design and Synthesis of s-Triazine derivatives as NLO materials
Kolupula Srinivas, V. Jayathirtha Rao, K. Bhanuprakash
Organic Synthesis and Process Chemistry, April, 2005, IICT, Hyderabad, India.
- Near-UV absorbing octopolar organic molecule for second harmonic generation (SHG): A combined experimental and theoretical insight
Kolupula Srinivas, Sanyasi Sitha, K. Bhanuprakash, V. Jayathirtha Rao, S. Ravikumar, S. P. Anthony, T. P. Radhakrishnan;
National Conference on Emerging Materials and Technologies, S. V. University, Tirupati (India), August 2004.
Invited Lectures :
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Invited Lecture @ National Conference on “Recent Advances in Bioactive Heterocycles” Conducted by H. Bahirji Smarak Mahavidyalaya, Hingoli (District), Maharastra; 22nd March 2012.
- Invited Lecture @ International Symposium on “Nanotechnology & Functional Materials” Jointly organized by Sreenidhi Institute of Science & Technology and University of South Africa; 7th January 2012.
- Invited Lecture @ National Symposium on “Chemistry: Our Life & Future” Sponsored by UGC & Conducted by NBKR Arts & Science College, Nellore, A. P., India; June 29th 2011
- Invited talk: “Workshop in Chemistry (Hands on Experience) conducted by Royal Society of Chemistry (London) Deccan Section, Hyderabad & NIPER-Hyderabad; April 8-9, 2011
- Invited Lecture in Scientific Plenary Session @ Conventus 2011: GITAM Pharma Fest; March 25-26, 2011, Visakapatnam, A. P. India
- Invited Lecture @ MEDCHEM Congress – 2011 by IICT, NIPER-Hyderabad & RSC, London; February 25-26, 2011
5. Oral Presentation in Dr. K.V.RAO Memorial Awards – 2006, Hyderabad, A.P
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