Dr. M.V.Narendra Kumar Talluri Assistant Professor Department of Pharmaceutical Analysis NIPER-Hyderabad E Mail:narendra@niperhyd.ac.in

Qualification:

• Ph.D; Chromatography & Mass spectrometry (Pharmaceutical Analysis)

Experience:

• Working as a Lecturer at NIPER-Hyderabad since 2009.
• Worked at Biocon Bristol-Myers Squibb Research Center as a Associate Scientific Manager

Research Area of Interest:

• Impurity Profiling and Metabolic profiling of Drugs
• Drug metabolism and Pharmacokinetics
• Stability studies/drug-drug interactions
• Bio-analytical research- SPE, SPME, GC-MS, LC-MS/MS
• Standardization of Herbal Drugs
• Method development and validation for Drugs and Pharmaceuticals

Awards and Honors:

• Research Fellowship awarded by CSIR
• Associate ship (AIC) awarded by Institute of Chemists
• Reviewer: Journal of Liquid Chromatography & Related Technologies, USA.
• Editorial Advisory Board-Member: Journal of Pharmaceutical Research and Clinical Practice
• Top 25 Hottest articles in Science Direct: 4 times (articles published in JPBA).
• Invited speaker, seminar on “Trends in Pharmaceutical Technology”, SCPS-JNTU, 2010.
• Invited speaker, “The importance and challenges of impurity profiling in modern pharmaceutical analysis”, SGIPS-ANU, 2011.
• Expert member/Resource person “Dr. Yallapragada Subbarao Research Forum” SGIPS, AN University.
• Prestigious “Young Pharmaceutical Analyst Award 2011” bestowed IDMA-APA PAC 2011.

Membership of Scientific Societies:

• Life member of Institute of Chemists, India.
• Member, IDMA-Association of Pharmaceutical Analysts (IDMA-APA).

Teaching & Guiding Research Projects:

• Separation Techniques (NP-510)
• Topics in Pharmaceutical Analysis (PA-510)
• Modern Instrumental Techniques for Evaluation of APIs and Drug Products (PA-620)
• Pharmacopoeial Methods of Analysis (PA-610)
• Standardization of Natural Product Drugs / Formulations (NP-630)
• Seminar (GE-511, GE-611)
• General Laboratory Experience (LG-510, LS -610)

Research Supervisor:

• Guiding the research work of M.S. (Pharm.Analysis) students –six nos.
• Completed: 6 MS (Pharm.Analysis) Research projects in Pharmaceutical Analysis
• Designed course-work for PhD in Pharmaceutical Analysis, NIPER-Hyderabad.

Publications:

• Development of a validated RP-LC/ESI-MS-MS method for separation, identification and determination of related-substances of tamsulosin in bulk drugs and formulations, Journal of Pharmaceutical and Biomedical Analysis 46 (2008) 94-103.
• Development and validation of a reversed phase liquid chromatographic method for separation and determination of related-substances of modafinil in bulk drugs Talanta 73 (2007) 407-414.
• Continuous counter current extraction, isolation and determination of solanesol in Nicotiana tobacum L. by non-aqueous reversed phase high performance liquid Chromatography Journal of Pharmaceutical and Biomedical Analysis 46 (2008) 310–315.
• An overview of recent applications of inductively coupled plasma-mass spectrometry (ICP-MS) in determination of inorganic impurities in drugs and pharmaceuticals (Review article) Journal of Pharmaceutical and Biomedical Analysis 43 (2007) 1-13.
• Simultaneous separation and determination of co-enzyme Q10 and its process related impurities by NARP-HPLC and atmospheric pressure chemical ionization-mass spectrometry (APCI-MS). Journal of Pharmaceutical and Biomedical Analysis 47 (2008) 230-237.
• Determination of heavy metals in selected drug substances by inductively coupled plasma-mass spectrometry, Indian Journal of Chemical Technology 12 (2005) 229-231.
• Enantioselective HPLC resolution of synthetic intermediates and related substances of armodafinil. Journal of Separation Science 31 (2008) 981-989.
• Estimation of trace lead impurity in haematopoietic drug samples by flame atomic absorption spectrometry, Asian Chemistry Letters 12 (2008) 57-60.
• Separation of sterioisomers of sertraline and its related enatiomeric impurities on a dimethylated β–Cyclodextrin stationary phase by HPLC, Journal of Pharmaceutical and Biomedical Analysis 50 (2009)281-286.
• LC-ESI-MS determination and pharmacokinetics of adrafinil in rats, Journal of Chromatography B 873 (2008) 119-123.
• Development and validation of RP-HPLC and ultraviolet spectrophotometric methods of analysis for simultaneous determination of paracetamol and larnoxicam in pharmaceutical dosage forms, Journal of Liquid Chromatography & Related Technologies (accepted).
• Development of a molecularly imprinted polymer for selective extraction followed by zwitterionic hydrophilic interaction liquid chromatography (ZIC-HILIC) determination of 3-methylflavone-8-carboxylic acid, the main active metabolite of flavoxate in human urine, Journal of Separation Science (accepted)

Books / Monographs:

• Book series entitled, “Comprehensive Bioactive Natural Products” published by Studium Press LLC, USA. (2010.) Vol. 6 Chapter on “Extraction, Isolation and Characterization of Solanesol from Nicotiana tobacum L.” R. Nageswara Rao and M.V. Narendra Kumar Talluri
• Book entitled, Impurity Profiling of Drugs and Pharmaceuticals. Published by LAP LAMBERT Academic Publishing AG &Co. KG, Germany (by Invitation).

Conference Papers:

• Invited speaker for a National Seminar on “Trends in Pharmaceutical Technology (PHARMASCAN)” conducted by SCOPS of JNT University-Hyderabad to delivered a talk on “Trends in Impurity Profiling of Drugs and Pharmaceuticals". on 28-29th Dec' 2010.
• Application of ICP-MS in Pharmaceutical Industry- a new dimension, in the Conference of Indian Council of Chemists, held at IIT, Roorke, Oct‟2003 (Oral presentation)
• Determination of traces of titanium in Esomeprazole magnesium by ICP-MS, 57th Indian Pharmaceutical Congress held at Hyderabad Dec 2006. (Oral presentation)
• Method development and validation for the Gas Chromatography-Flame Ionization Detection assay of ethanol in Arishtas (Ayurvedic formulations), in the “International Conference on Resent Advances in Drug Discovery”. Organized by Kakatiya University, Warangal. A.P., Oct. 22-24th, 2010 (Oral presentation) M.V.N.KumarTalluri*, Anitha Kalyankar, Naveen Reddy Kandimalla, D. Subrahmanyam
• Drug-excipient interaction study of cyclobenzaprine hydrochloride with different pharmaceutical excipients by RP-HPLC, DSC, XRD and FT-IR. in the “4th Conference on Recent Trends in Instrumental Methods of Analysis, Department of Chemistry, Indian Institute of Technology, Roorkee. Feb. 18 - 20th Feb 2010. M.V.N. Kumar Talluri*, Amit k. jain, Nirav N. jadav , K.V.Lalitha
• Development and validation of a stability indicating high performance liquid chromatographic method for determination of Zotepine-an antipsychotic drug in presence of its degradation products, National seminar on Recent advances in Analytical sciences- Indian perspective (RAASI) organized by Indian Society of Analytical Scientist (ISAS), Hyderabad Chapter and IICT, Hyd., M.V.N.Kumar Talluri*, Naveen Reddy Kandimalla, and Amit K. Jain
• Validated stability indicating RP-HPLC assay method for simultaneous determination of chlorzoxazone and ibuprofen in bulk drugs and formulations, National seminar on Recent advances in Analytical sciences- Indian perspective (RAASI) organized by Indian Society of Analytical Scientist (ISAS), Hyderabad Chapter and IICT, Hyd. M.V.N.Kumar Talluri*, Amit K. Jain, K.V.Lalitha.
• A Stability indicating high performance liquid chromatographic method for simultaneous determination of Amlodipine and Perindopril in Bulk drugs and Dosage form, Separation Science Asia 2011 (Biopolis, Singapore; 27-28 July). M.V.N.Kumar Talluri*, H.H. Theja Dugga. (accepted for poster)
• Separation, determination of atorvastatin, an antihyperlipidemic drug in synchronization with antihypertensive, antidiabetic, antithrombotics by using reversed phase high performance liquid chromatography in combined dosage formulations, Separation Science Asia 2011 (Biopolis, Singapore; 27-28 July). M.V.N.Kumar Talluri*, Anitha Kalyankar.(accepted for poster)

Seminars/Training programmes:

• Workshop On “Fundamentals of Clinical Research & Good Clinical Practice” of ACADEMY FOR CLINICAL EXCELLENCE held at ITC Kakatiya Sheraton, Hyderabad 18 - 20 October 2007.
• National Conference on “Ayurvedic Medicare as Evidence based Medicine” organized by I.S.E.R.V.E. (Institute of Scientific Research on Vedas), held on 16-17, Feb, 2006, Hyderabad.
• 57th Indian Pharmaceutical Congress held at Hyderabad in Dec‟2006.
• Seminar on “Analytical Chemistry-Drugs & Pharmaceuticals” of Indian Society of Analytical Scientists (ISAS) held on 12th Mar.2004 at IICT, Hyderabad
• American Chemical Society‟s short course in Capillary Gas Chromatography & High Pressure Liquid Chromatography “How to Develop and Trouble Shoot GC and HPLC methods” on Feb 19- 20, 2004.
• 22nd Conference of Indian Council of Chemists (ICC), Indian Institute of Technology, Roorkee. Oct‟2003. International seminar on “Global scenario of Herbal Medicine”, of Indo German Nachkontakt Association (IGNA), 19-20 Sep, 2003.
• The Millennium 52nd Indian Pharmaceutical Congress held at Hyderabad from 1-3rd Dec‟2000.
• National Seminar on Analytical Chemistry-Vision 2020, March- 2008, IICT, Hyderabad.
• 2nd International Symposium on Drug Metabolism and Pharmacokinetics (DMPK) Applications toward Drug Discovery and Development jointly organized by Bristol-Myers Squibb and NIPER, S.A.S. Nagar 160 062, Punjab, India on 27-28th Feb. 2010
• Workshop on „Computer Aided Drug Design and Discovery‟ (CAD3) -2010” was organized by NIPER-Hyderabad and VLife Sciences Technologies Pvt. Ltd., Pune from 30th April to 2nd May 2010.(organizing committee)
• UPLC workshop on “Proteins, peptides and amino acids” on 07 June 2010 organized by Waters India Pvt. Ltd. Secunderabad.
• Workshop on Drug Discovery, Drug Design, Development, Delivery and Preclinical Studies (D4PS) from 8 -9th Oct.2010 at NIPER and IICT-Hyderabad. (Organizing committee).
• The United States Pharmacopeial Convention conducted “IPC-USP Science Standards Symposium 2011” on 17-18th Feb 2011, Hyderabad.
• Training course on “High resolution Mass spectrometry (HRMS)” conducted by Waters India Pvt. Ltd, Bangalore.