National Institute of Pharmaceutical Education and Research
Dept. of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India NIPER HYDERABAD
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Home >> Research >> Research at NIPER-Hyderabad

Research at NIPER-Hyderabad

Research at NIPER-Hyderabad is conducted in all departments. NIPER-Hyderabad has been actively pursuing the following research areas:
    Drug Discovery & Development
  • Focus Areas: Cancer, diabetes, inflammation, infectious diseases & rare diseases
    1. Medicinal chemistry ; Molecular modeling; IP evaluation
    2. In vitro / in vivo biology
    3. Process chemistry ; Formulation development
    4. Regulatory toxicology
    Product Development
  • Focus areas: Development of novel formulations, efficient & cleaner processes and development of appropriate analytical methods
  • 1. Formulation development ; IP evaluation
    2. Process chemistry ; Scale up technologies
    3. Pharmaceutical analysis
    4. Toxicology studies

Follow these links to learn in detail about the ongoing research activities in department wise.

Medicinal Chemistry

This department is working in multi-disciplinary research programmes including organic synthesis, medicinal, combinatorial and green chemistry including chemical biology. The main objective of the department is to design and synthesis of new chemical entities for anti-cancer, anti-inflammatory, anti-depressant, anti-tubercular and anti-microbial activity in the drug discovery programme. The targets are selected based on the structural information obtained from ligand-protein crystallographic structures, molecular modeling, novel molecular architecture, important biological activity and interesting mechanism of action. Next, a number of newly synthesized molecules could be tested their biological profile by complete in vitro studies on selected cell lines particularly based on the biological targets with complete mechanism of action. We are also devising new and alternative synthetic strategies for the construction of complex bioactive natural/unnatural molecules or building blocks or chiral molecules that are very useful in both basic and applied pharmaceutical sciences.

The department is engaged in the following areas of research
  • To discover and develop New Chemical Entities (NCEs) to cure cancer, inflammation, tuberculosis and bacterial infection.
  • The application of Computational Chemistry for the design of new molecules of medicinal significance.
  • Synthesis and biological evaluation of NCEs related to inhibition of various Tyrosine Protein Kinases (kinase-privileged scaffold).
  • Molecules acting on topoisomerase enzyme and peroxisome proliferator-activated receptor- (PPAR-).
  • Acting on Microtubules and Kinesin Spindle Enzyme.
  • NCEs causing the induction of Apoptosis.
  • Discovery of novel modulators of human HDAC2 using computational approach.
  • Development of new DNA interactive compounds (groove binders and intercalators) as anticancer agents.
  • Combinatorial synthesis.
  • Asymmetric synthesis of natural products of pharmacological importance.
  • Asymmetric synthesis of chiral bioactive molecules.
  • Development of new efficient synthetic methodologies for biologically active scaffolds.
  • Development of green synthetic methodologies and their applications in the synthesis of bioactive molecules.
  • Development of efficient homogenous/heterogeneous transition-metal catalysts and their application in various synthetic strategies.
  • Online ESI-MS mechanistic studies to study the reaction mechanism and their reactive intermediates.
  • One-pot syntheses of complex molecules from simple starting materials.
  • Microwave-assisted synthesis.
  • Computer Aided Drug Design (CADD): Target-based drug design, Pharmacophore modelling, Quantum Mechanical modelling, Homology modelling, Molecular simulations, etc.

Process Chemistry

Development of newer, environmentally friendly and cost-effective process technologies

Manufacturing of active pharmaceutical ingredients (APIs) and key intermediates requires long sequence of chemical reactions and large quantities of solvents. Production of hazardous waste as side products in these processes, poses a great threat to the environment. Therefore, the process R&D focuses on developing faster, cheaper, efficient and more environmentally friendly processes.
With the above in mind, the department of Process Chemistry has initiated research on the following areas.
  • Development of more efficient catalysts, which can help in reducing the number of steps or to make the conversion more efficient are being developed viz., novel organo catalysts, bio-catalysts.
  • Developing new process technologies viz., Micro reactors, Nano-encapsulation, which reduces multistep reactions to one-pot processes; Parallel and Continuous processing, which enables scientists to run many experiments at one time; Continuous reactions, which aim to eliminate batch processing, and vastly reduces the solvent usage.
  • Exploration of various techniques for the preparation of Chiral drugs viz., bio-transformations, and newer reagents/catalysts. Novel biological methods are also being explored for recycling the waste from the chemical reactions into desirable pharmaceutical compounds.
  • Developing green technologies for the manufacture of APIs and intermediates, which minimizes the production of waste.

The department is engaged in the following areas of research
  • Development of efficient synthetic routes for the preparation of low volume – high cost APIs
  • Discovery & development of novel anti-bacterial agents
  • Discovery & development of novel anti-cancer agents

Pharmaceutical Analysis

The principal remit of the department is the discovery, development and application of analytical methods and techniques relevant to pharmaceutical and biomedical sciences.

The department specializes in training pharmacists and chemists in developing their knowledge and problem solving skills in pharmaceutical analysis.

Research projects are currently under way in a range of general and specific analytical problems utilizing a variety of instrumental techniques. Chromatographic techniques are widely used with high-performance/Ultra performance liquid chromatography and gas chromatography being strongly to the fore and LC-MS/MS and GC-MS studies of drugs and drug metabolites.

Chemometric methods of analysis are used to give a deeper perspective to the results and to allow data to be compared more easily.
The department is engaged in the following areas of research
  • Drug impurity profiling
  • Stability studies
  • Analysis and standardization of herbal drugs
  • Drug metabolism studies
  • Bioanalytical method development

Pharmacology & Toxicology

The main focus of this department is to offer extensive training in pharmacology and toxicology to both post graduate (MS Pharm) and Ph.D students. Our program features close working relationships between individual students and their faculty mentor, rich and diverse research opportunities, and individualized programs of study based on the needs of the students.

The research program is founded on a strong Ph.D graduate program in Pharmacology & Toxicology. Current areas of research investigation in the department are neuropharmacology especially in peripheral neuropathies, effects of diabetes and chemotherpay on the nervous system, Chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, gout, cancer and inflammation/cancer induced bone loss.
The department is engaged in the following areas of research
  • Diabetes and Diabetic complications
  • Cancer
  • Cancer induced bone loss
  • Rheumatoid arthritis and Psoriasis
  • Gout and Urolithosis

Regulatory Toxicology

Regulatory toxicology can be known for its multi-disciplinary knowledge that aggregates pharmacology, Regulatory and Toxicology studies. It is mainly focused on assuring safety of drugs that can be done by toxicological studies by strictly following different regulatory guidelines. These studies are conducted according to the standardized protocols. Today in most of the pharmaceutical industries conducting the regulatory toxicology studies have become utmost important aspect in order to take the new chemical entities (NCEs) into clinical trials. The battery of regulatory toxicology and safety pharmacology studies need to be submitted to get the approval for clinical trials from concerned regulatory authorities. Currently in many pharmaceutical industries, there is a huge shortage of specialized scientist in regulatory toxicology areas. Therefore, there would be an ample of opportunities for the trained personnel to contribute to the growth of Indian pharmaceuticals industry. Further, there is a great need for Regulatory Toxicology experts in cosmetic industry to evaluate safety of various cosmetic formulations. Another important aspect needs immediate attention is safety evaluation of various nanotechnology based formulations. There are no set guidelines available to conduct the toxicological studies of nanoformulations

The department is engaged in the following areas of research
  • Nanotoxicology studies
  • Regulatory toxicology studies
  • Therapeutic evaluation of natural products in pulmonary fibrosis and other fibrotic conditions
  • Pharmacological and toxicological effects evaluation of nanoparticles in inflammatory and oxidative stress mediated disorders
  • Strategies to overcome tumor fibrosis to improve anticancer effects
  • Identifying novel agents to treat acute and chronic pancreatitis
  • Developing novel delivery systems to treat psoriasis, type 1 diabetes and cancer etc.

Pharmaceutics

Research in the Pharmaceutics Department encompasses basic, applied, and clinical investigations in preformulation, drug delivery, and stability studies. The spacious laboratories are well equipped with state of art facilities like tablet punching and coating machine, FBD, Wurster coater, tray drier, spray drier, lyophilizer, granulator, etc to conduct both bench scale and pilot plant operations for conventional formulations. In addition, equipments like probe sonicators, homogenizers, microfluidizer, ultracentrifuges, zetasizer, facilitate undertaking research in the area of NDDS. Advanced software tools operating on higher end configuration computers are also provided to aid model development, simulation and prediction of various pharmaceutical process related operations.

The major thrust area of the pharmaceutics department is drug delivery. Recent efforts in the area of drug delivery include the development of Immediate Release systems, Modified drug delivery systems including Novel Drug Delivery Systems (NDDS), Targeted Drug Delivery systems like nanotechnology based drug delivery and ligand conjugate based delivery systems. A newly established SSPRG (Solid State Pharmaceutical Research Group) in the department has its exclusive focus on developing and characterizing various solid state pharmaceuticals like cocrystals, isomorph, polymorphs.

The department is engaged in the following areas of research
  • Bioavailability improvement techniques based on nanotechnology, lipid-based formulations, complexation, mesoporous DDS.
  • siRNA delivery and Pgp efflux inhibitor systems with a focus on cancer therapy
  • Development of various NDDS like TDDS, niosomes, gels, matrix and coated particulate systems.
  • Formulation and stabilization of nutraceuticals and herbal drug delivery.
  • Gold coated sutures for wound healing
  • Solid state manipulation in area of crystal habits, polymorphs, cocrytals and multicomponent systems.
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