The department is engaged in the following areas of research

• Identification and validation of novel target sites for various therapeutic areas: Design and synthesis of new chemical entities as anticancer, antileishmanial, broad-spectrum antimalarial, antituberculosis, antihypertensive, antiinflammatory, antidiabetic compounds and multi-drug resistance reversal agents
• Asymmetric Synthesis: Development of methodologies for catalytic asymmetric synthesis-dynamic kinetic resolution, asymmetric protonation/ deprotonation, asymmetric epoxidation, asymmetric aziridation and asymmetric alkylation. Synthesis of chiral drugs
• Combinational Chemistry: Development of novel linkers and analytical protocols; generation of molecular libraries
• Peptide Synthesis: Synthesis of unnatural amino acids and their incorporation in the peptides of biological importance by using solution- and solid- phase synthesis protocols. Receptor binding studies on the TRH peptides
• Eco-friendly Processes: Development of new methodologies under solvent free condition, surface mediated reactions, microwave/ ultrasound assisted enhancement of reaction rates
• Computer Aided Drug Design: Molecular modeling methods based on molecular mechanics, Quantum mechanics. Analog based design of - Kinase, Phosphatase, Protease, HMG-CoA reductase, selective COX-2, and selective PDE4 inhibitors. PPAR- g and Angiotensin receptor antagonist, Alzeimer dementia by 3D-QSAR, CoMFA, and docking methods